Abstract
Among 30 patients of myeloma, 2 cases were recognized to develop manifestations suggestive of amyloidosis during the clinical courses. Both Japanese females, with an age of 50- and 55-year-old, respectively, had been instituted on myeloma chemotherapy of continuous low-dose melphalan-prednisolone administration. Marked changes in the clinical features were noted around 6 to 10 months prior to their deaths. Subjectively, they started to have complaints of lassitude and palpitation. Objective findings included weight loss, decreased both blood pressure and pulse pressure, obvious appearance of macroglossia, cardiac arrythmia and abnormal cardiac echograms.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Isobe, T. and Osserman, EF. (1974) Patterns of amyloidosis and their association with plasma cell dyscrasia, monoclonal immunoglobulins and Bence Jones proteins. N Engl J Med 290, 473–477.
Isobe, T. (1989) AL amyloidosis: A metabolic disease. Haematologica 74, 425–429.
Kyle RA, Bayrd ED: Amyloidosis: review of 236 cases. Medicine (Baltimore) 54: 271–299, 1975.
Scott PP, Scott WW, Siegelman SS (1986), Amyloidosis: an overview: Seminars in Roentgenol 21, 103–112.
Isobe, T, Tonoike H, Kametani F, Shinoda T. (1986) Amyloidogenicity and subgroups of human lambda Bence Jones proteins. In Amyloidosis ed by Glenner GG et al New York, Plenum pp. 477–481.
Cohen, A. and Connors, LH. (1987) The pathogenesis and biochemistry of amyloidosis. J Pathol 151, 1–10.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Isobe, T., Matozaki, S., Fujita, T., Shinoda, T. (1991). Clinical Indications of Systemic Amyloidosis in Myeloma Patients. In: Natvig, J.B., et al. Amyloid and Amyloidosis 1990. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3284-8_55
Download citation
DOI: https://doi.org/10.1007/978-94-011-3284-8_55
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5450-8
Online ISBN: 978-94-011-3284-8
eBook Packages: Springer Book Archive