Problems and Progress in Computational Approaches to the Molecular Basis of Recognition
Computational methods for identifying functional properties of proteins are briefly discussed. The methods lead to the concept of structure-function motif. A specific example is alpha amphipathicity as an indicator of antigenicity. This motif, though useful for planning experiments, is not sufficiently reliable to provide the basis for vaccine design. Recent progress on docking strategies based on structural analyses may provide methods that will be useful for both protein and nucleic acid receptors.
KeywordsAntigenic Site Phospho Choline Protein Structure Determination Serine Proteinase Domain Amino Acid Variability
Unable to display preview. Download preview PDF.
- Benham, C. J. (1986) Superhelical DNA, Comments Mol. Cell Biophys. 4: 35–54.Google Scholar
- C. Branden and J. Tooze (1991), Introduction to Protein Structure, Garland Publishing Inc., New York.Google Scholar
- Rosenfeld, R., M. Colbert, N. Soohoo and C. DeLisi, in preparation.Google Scholar
- DeLisi, C., J. Cornette, H. Margalit, K. Cease, and J. A. Berzofsky (1987) The role of amphipathicity as an indicator of T-cell antigenic sites on proteins Ili. Immunogenicity of Protein Antigens: Repertoire and Regulation. Sercarz, E.G., and Berzofsky, J.A. (Eds) CRC Press, Boca Raton. Vol 1, 35–42Google Scholar
- Sezerman, O. S., S. Vajda, and C. DeLisi. Docking of flexible peptides to compliant receptors with applications to ligand-MHC interactions, SubmittedGoogle Scholar
- Brower R. C. and C. DeLisi Impact of massively parallel computation on protein structure determination, SubmittedGoogle Scholar