Left Ventricular Mass as a Measure of Preclinical Disease in Patients with Hypertension

  • Richard B. Devereux
  • Michael J. Koren
  • Mary J. Roman
  • John H. Laragh
Part of the Medical Science Symposia Series book series (MSSS, volume 1)

Abstract

Although hypertension is diagnosed based on elevation of arterial blood pressure, its clinical significance derives from morbid events affecting the heart, brain, and kidneys. However, the morbid events that most commonly complicate hypertension-myocardial infarction, sudden cardiac death and atherothrombotic brain infarction—are not directly due to blood pressure elevation, but rather to hypertension-induced cardiac and vascular damage. These structural abnormalities constitute preclinical hypertensive disease, among which the manifestation that has been best studied in patients is cardiac hypertrophy, detected by echocardiographic measurement of left ventricular (LV) mass (8).

Keywords

Cardiac Hypertrophy Left Ventricular Mass Morbid Event Concentric Left Ventricular Hypertrophy Increase Left Ventricular Mass 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Blake J., Devereux R. B., Herrold E. Mc. M., Jason M., Fisher J., Borer J. S., Laragh J. H. (1988):Am J Cardiol, 62:246–252.PubMedCrossRefGoogle Scholar
  2. 2.
    Casale P. N., Devereux R. B., Milner M., Zullo G., Harshfield G. A., Pickering T. G., Laragh J. H. (1986):Ann Intern Med, 105:173–178.PubMedCrossRefGoogle Scholar
  3. 3.
    Cooper R. S., Simmons B. E., Castaner A., Santhanam V., Ghali J., Mar M. (1990):Am J Cardiol, 65:441–445.PubMedCrossRefGoogle Scholar
  4. 4.
    Craven T. E., Ryu J. E., Espeland M. A., Kahl F. R., McKinney W. M., Toole J. F, McMahon M. R., Thompson C. J., Heiss G., Crouse J. R. III. (1990):Circu1ation, 82:1230–1242.CrossRefGoogle Scholar
  5. 5.
    Dellsperger K. C., Clotheir J. L., Hartnett J. A., Haun L. M., Marcus M. L. (1988):Cir Res, 63:87–96.CrossRefGoogle Scholar
  6. 6.
    deSimone G., Devereux R. B., Roman M. J., Schlussel Y., Alderman M. H., Laragh J. H. (1991):Ann Intern Med, 114:202–209.PubMedCrossRefGoogle Scholar
  7. 7.
    Devereux R. B. (1990):In Hypertension: Pathophysiology. Diagnosis. Treatment. edited by J. H. Laragh and B. M. Brenner pp 359–377. Raven Press, New York.Google Scholar
  8. 8.
    Devereux R. B., Reichek N. (1977):Circulation, 55:613–618.PubMedCrossRefGoogle Scholar
  9. 9.
    Gottdiener J. S., Brown J., Zoltick J., Fletcher R. D. (1990):Ann Intern Med, 112:161–166.PubMedCrossRefGoogle Scholar
  10. 10.
    Hammond I. W., Devereux R. B., Alderman M. H., Lutas E. M., Spitzer M. D., Crowley J. S., Laragh J. H. (1986):J Am Coll Cardiol, 7:639–650.PubMedCrossRefGoogle Scholar
  11. 11.
    Harshfield G. A., Grim C. E., Hwang C., Savage D. D., Anderson S. J. (1990):Am J Hypertens, 3:538–543.PubMedGoogle Scholar
  12. 12.
    Koren M. J., Devereux R. B., Casale P. N., Savage D. D., Laragh J. H. (1991):Ann Intern Med, 114:345–352.PubMedCrossRefGoogle Scholar
  13. 13.
    Koren M. J., Savage D. D., Casale P. N., Laragh J. H., Devereux R. B. (1990):Circulation, 82 (Supp1ement):III–29.Google Scholar
  14. 14.
    Koyanagi S., Eastham C. L., Harrison D. G, Marcus M. L. (1982):Circ Res, 50:55–62.PubMedCrossRefGoogle Scholar
  15. 15.
    Koyanagi S., Eastham C., Marcus M. L. (1982):Circulation, 65:1192–1198.PubMedCrossRefGoogle Scholar
  16. 16.
    Levy D., Garrison R. J., Kannel W. B., Castelli W. P. (1990):N Engl J Med, 323:1706–1707.CrossRefGoogle Scholar
  17. 17.
    Levy D., Garrison R. J., Savage D. D., Kannel W. B., Castelli W. P. (1989):Ann Intern Med, 110:101–108.PubMedCrossRefGoogle Scholar
  18. 18.
    Levy D., Garrison R. J., Savage D. O., Kannel W. B., Castelli W. P. (1990):New Engl J Med, 322:1561–1566.PubMedCrossRefGoogle Scholar
  19. 19.
    Martins J. B., Kim W., Marcus M. L. (1989):J Am Coll Cardiol, 14:1365–1373.PubMedCrossRefGoogle Scholar
  20. 20.
    Nestrova A. L., Novikov I. D., Yurenev A. P. (1986):Kardiologiia, 8:89–91.Google Scholar
  21. 21.
    Roman M. J., Spitzer M., Pini R,., Alderman M. H., Devereux R. B. (abstr) (1991):J Am Coll Cardiol, 17:222A.CrossRefGoogle Scholar
  22. 22.
    Silberberg J. S., Barre P. E., Prichard S. S., Sniderman A. D. (1989):Kidney Intl, 36:286–290.CrossRefGoogle Scholar
  23. 23.
    Topol E. J., Traill T. A., Fortuin N. J. (1985):N Engl J Med, 312:277–283.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1992

Authors and Affiliations

  • Richard B. Devereux
  • Michael J. Koren
  • Mary J. Roman
  • John H. Laragh

There are no affiliations available

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