SERS of a Series of New Substituted Ellipticinium Derivatives and their Complexes to DNA
Chapter
Abstract
The natural plant alkaloid ellipticine and some of its quaternarized derivatives are used as antitumor agents in the treatment of various human cancers. These molecules are planar conjugated aromatic systems and bind strongly to DNA by intercalation.1 It has been postulated that their oxidative activation at C(9) leads to a quinone imine intermediate (ie. NMOE; scheme 1) which reacts with biological molecules such as amino acids, proteins or nucleic acids, that contain suitable nucleophilic groups, to give covalent adducts through a Michael addition at C(10). In the case of primary amines, recyclization process occurs during coupling leading to oxazolopyridocarbazole (OPC) adducts.2
Keywords
Primary Amine Biological Molecule Antitumor Agent Michael Addition Recyclization Process
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
- 1 -.M.A. Schwaller, G. Dodin and J. Aubard, (1991), Biopolymers. 31, 519.PubMedCrossRefGoogle Scholar
- 2 -.C. Auclair, (1987), Arch. Biochem. Biophys., 259, 1.PubMedCrossRefGoogle Scholar
- 3 -.J.C. Rukdeshel et al, (1992), J. Med. Chem., 35, 4854.CrossRefGoogle Scholar
- 4 -.J. Aubard, M.A. Schwaller, J. Pantigny, J.P. Marsault and G. Lévi, (1992), J. Raman Spectrosc., 23, 373.CrossRefGoogle Scholar
Copyright information
© Springer Science+Business Media Dordrecht 1993