In Vivo Monitoring with Microdialysis Probe
Using a sterilized hollow fiber as microdialysis probe, placed subcutaneously and a glucose biosensor, we were able to monitor the variation of glucose during a glucose load (in the bloostream with rabbit and oral with humans). The technique revealed good stability of the glucose sensitivity of the probe during the experiments (up to three hours) and a fair correlation of the glucose values in blood and subcutaneously. In few cases with humans (3 of 15) we found a delay of 30 min.
KeywordsHollow Fiber Continuous Monitoring Glucose Load Point Calibration Continuous Glucose Monitoring
Unable to display preview. Download preview PDF.
- 4.Moscone D., Mascini M., Microdialysis and glucose biosensor for in vivo monitoring Ann. Biol. Clin. 50(1992), 323Google Scholar
- 5.Vadgama P., Desai M.A., In vivo Biosensors from biosensors principles and applications (Blum L.J., Coulet P.R., eds) M. Dekker Inc, New York, 303–338 (1991)Google Scholar
- 6.Moscone D., Mascini M., Microdialysis coupled with glucose biosensor for subcutaneous monitoring Analusis 21(1993), M40–M42Google Scholar