Pharmacological Aspects of Calcium Channels in Nonvascular Smooth Muscle

  • David J. Triggle
Chapter
Part of the Medical Science Symposia Series book series (MSSS, volume 3)

Abstract

Smooth muscle is a heterogeneous tissue. However, a key component of excitation-contraction coupling in both vascular and nonvascular smooth muscle is an elevation of intracellular calcium subsequent to excitation. The processes by which intracellular calcium is elevated from the resting level of approximately 10-8M to the stimulated level of approximately 10-6M are quite diverse in smooth muscle and depend on tissue stimulus, component of response, and pathology (1,2).

Keywords

Calcium Antagonist Tonic Component Drug Binding Site Smooth Muscle Preparation Ileal Smooth Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bolton T.B. (1979): Physiol Rev., 43: 606–718.Google Scholar
  2. 2.
    Hurwitz L. (1986): Ann. Rev. Pharmacol Toxicol, 26: 225–258.CrossRefGoogle Scholar
  3. 3.
    Bean B.P. (1989): Ann. Rev. Physiol., 51: 367–384.CrossRefGoogle Scholar
  4. 4.
    Tsien R.W. and Tsien R.Y. (1990): Ann. Rev. Cell Biol , 6: 715–760.PubMedCrossRefGoogle Scholar
  5. 5.
    Miller R.J. (1987): Science, 235: 46–52.PubMedCrossRefGoogle Scholar
  6. 6.
    Triggle DJ. (1990): In: Cardiovascular Pharmacology, edited by M. Antonaccio. Raven Press, New York.Google Scholar
  7. 7.
    Glossmann H. and Striessnig J. (1989): Rev. Physiol Biochem. Pharmacol, 114: 1–105.CrossRefGoogle Scholar
  8. 8.
    Janis R.A., Silver P.J. and Triggle D.J. (1987): Adv. Drug Res., 16: 307–591.Google Scholar
  9. 9.
    Wei X.-Y., Luchowski E.M., Rutledge A., Su C.M. and Triggle DJ. (1986): J. Pharmacol Exp. Therap., 70:Google Scholar
  10. 10.
    Yousif F.B., Bolger G.T., Ruzycky A. and Triggle D.J. (1987): Can. J. Physiol PharmacoL, 63: 453–462.CrossRefGoogle Scholar
  11. 11.
    Triggle D.J., Zheng W., Hawthorn M., Kwon Y.-W., Wei X.-Y., Joslyn A., Ferrante J. and Triggle A.M. (1989): Ann. N.Y. Acad. Sci., 560: 215–229.PubMedCrossRefGoogle Scholar
  12. 12.
    Triggle D.J. (1992): Cleveland Clinic J. Med., (in press).Google Scholar
  13. 13.
    Triggle D.J., Hawthorn M. and Zheng W. (1988) J. Cardiovasc. Pharmacol, 12(suppl.4): S91-S93.CrossRefGoogle Scholar
  14. 14.
    Yousif F.B. and Triggle D.J. (1985): Can. J. Physiol Pharmacol, 64: 273–283.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1993

Authors and Affiliations

  • David J. Triggle
    • 1
  1. 1.School of PharmacyState University of New York at BuffaloBuffaloUSA

Personalised recommendations