Drugs Affecting Lipid Metabolism pp 453-466 | Cite as
Atherogenicity of Triglyceride-Rich Lipoproteins: Clinical Aspects
Chapter
Abstract
A growing body of evidence suggests that triglyoeride-rich particles in the plasm contribute to the process of atherogenesis. Some nay do so directly while others operate by proxy through their influence on circulating cholesterol-rich lipoproteins. Here we describe recent studies which assessed the influence of triglyceride on low density lipoprotein structure and metabolism. Our observations are consistent with the view that the shrinkage in LDL size which occurs with increasing plasma triglyceride is associated with defective binding of the lipoprotein to its receptor and channelling of its catabolism into potentially atherogenic receptor-independent pathways. Fibrate therapy, which lowers plasm triglyceride, reverses these phenomena and redirects the clearance of IDL towards the receptor route.
Keywords
Density Lipoprotein Coronary Heart Disease Risk Plasma Triglyceride Plasma Triglyceride Level Plasma Radioactivity
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