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Animal Models of Systemic Lupus Erythematosus

  • Chapter
Immunology of the Connective Tissue Diseases

Part of the book series: Immunology and Medicine Series ((IMME,volume 22))

Abstract

Since the aetiology and pathogenesis of autoimmune diseases are not clear 1,2, it is evident that the pathogenesis of these diseases cannot readily be analysed without appropriate animal models. These models may help to define aetiology, determine pathogenesis,and design innovative therapies. Indeed, systemic lupus erythematosus(SLE), as well as other autoimmune diseases, has animal models. Not surprisingly, they vary considerably in the ‘closeness of fit’ to the human disease they are supposed to be mimicking. These models have been the subject of intense study for the last several years. Although our understanding of human autoimmune diseases has certainly been increased by insights gained from studies in animal models, it has become painfully clear that pathogenic mechanisms or therapeutic success observed in one strain may not operate and/or may fail in the others 3.

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  1. D. Buskila
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  2. Y. Shoenfeld
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  1. Guy’s Hospital, London, UK

    G. S. Panayi (ARC Professor of Rheumatology) (ARC Professor of Rheumatology)

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Buskila, D., Shoenfeld, Y. (1994). Animal Models of Systemic Lupus Erythematosus. In: Panayi, G.S. (eds) Immunology of the Connective Tissue Diseases. Immunology and Medicine Series, vol 22. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1432-5_9

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