Drugs Eicosanoids pp 1771-1772 | Cite as
15-Hete
Chapter
Abstract
Oxygenation of arachidonic acid by lipoxygenases in leukocytes to produce the 5-hydroxy-derivatives is accompanied by 15-oxygenation resulting in the production of 15-hydroxyeicosatetraenoic acid (15-HETE). This is an important physiologically active product that inhibits the activity of 5-lipoxygenase in neutrophils and of 12-lipoxygen-ase in platelets and is thus part of the complex network of regulatory interactions between the various lipoxygenase pathways.
Keywords
Arachidonic Acid Solvent Extraction Solid Phase Extraction Complex Network Active Product
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Copyright information
© Springer Science+Business Media New York 1995