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Spectrofluorimetric Investigation of Multidrug Resistant Versus Sensitive Cells Using JC-1

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Spectroscopy of Biological Molecules
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Abstract

Some tumor cells become resistant to structurally unrelated antitumor drugs. The multidrug resistance phenotype (MDR) is characterized by a lowering of drug cellular accumulation associated with the expression of a 170-kDa glycoprotein, Pgp (Permeability glycoprotein) at the membrane level [for review see: Gottesman and Pastan, 1993; Simon and Schindler, 1994].

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© 1995 Springer Science+Business Media Dordrecht

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Kühnel, J., Ferte, J., Sureau, F., Schwaller, M. (1995). Spectrofluorimetric Investigation of Multidrug Resistant Versus Sensitive Cells Using JC-1. In: Merlin, J.C., Turrell, S., Huvenne, J.P. (eds) Spectroscopy of Biological Molecules. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0371-8_243

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  • DOI: https://doi.org/10.1007/978-94-011-0371-8_243

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4166-9

  • Online ISBN: 978-94-011-0371-8

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