Effect of tumour growth on inflammatory macrophages

  • D. Nolibe
  • R. Masse
  • J. P. Giroud
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)


Studies in many laboratories have led to the speculation that macrophages probably play a significant role in host defence against neoplasia. It has been shown both in vitro and in vivo that macrophages can destroy tumour cells via different pathways, specific1 or otherwise2. On the other hand it has been demonstrated that patients with neoplasms have a depressed monocyte chemotactic responsiveness3 and that macrophage accumulation in response to inflammatory stimuli is impaired during growth of experimental tumours4,5.


Alveolar Macrophage Mycobacterium Bovis Macrophage Accumulation Macrophage Response Inflammatory Macrophage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Alexander, P. (1976). The functions of the macrophage in malignant disease. Ann. Rev. Med., 27, 207PubMedCrossRefGoogle Scholar
  2. 2.
    Zbar, B., Bernstein, I. D., Bartlett, G. L., Hanna, N. G., and Rapp H. J. (1972). Immunotherapy of cancer: regression of intradermal tumors and prevention of growth of lymph node metastases after intralesional injection of living mycobacterium bovis. J. Natl. Cancer Inst., 49, 119PubMedGoogle Scholar
  3. 3.
    Snyderman, R., Seigler, H. F. and Meadows, L. (1977). Abnormalities of monocyte Chemotaxis in patients with melanoma; effects of immunotherapy and tumor removal. J. Natl. Cancer Inst., 58, 37PubMedGoogle Scholar
  4. 4.
    Snyderman, R., Pike, M. C, Blaylock, B. L. and Weinstein, P. (1976). Effects of neoplasms on inflammation: depression of macrophage accumulation after tumor implantation. J. Immunol., 116, 585PubMedGoogle Scholar
  5. 5.
    Normann, S. J., Schardt, M. and Sorkin, E. (1979). Cancer progression and monocyte inflammatory dysfunction: relationship to tumour excision and metastasis. Int. J. Cancer, 23, 110PubMedCrossRefGoogle Scholar
  6. 6.
    Normann, S.J. and Schardt, M. (1978). A macrophage inflammation test using subcutaneous nitrocellulose filters. J. Reticuloendothial Soc., 23, 153Google Scholar
  7. 7.
    Normannn, S.J. and Schardt, M. (1978).A cancer related macrophage dysfunction in inflamed tissues. J. Reticuloendothelial Soc., 24, 147–159Google Scholar
  8. 8.
    Nolibe, D., Masse, R., and Lafuma, J. (1980). The effect of neonatal thymectomy upon lung cancers induced in rats by 239 plutonium dioxide. Radiat Res. (In press)Google Scholar
  9. 9.
    Normann, S. J. and Cornelius, J. (1978). Concurrent depression of tumor macrophage infiltration and systemic inflammation by progressive cancer growth. Cancer Res., 38, 3453PubMedGoogle Scholar
  10. 10.
    Gauci, C. L., Wrathmell, A. and Alexander, P. (1975). The origin and role of blood born monocytes in rats with transplanted myelogenous leukemia. Cancer Lett. 1, 33PubMedCrossRefGoogle Scholar
  11. 11.
    Jamasbi, R. J., Nettesheim, P. and Kennel S.J. (1978). Demonstration of cellular and humoral immunity to transplantable carcinomas derived from the respiratory tract of rats. Cancer Res., 38, 261PubMedGoogle Scholar
  12. 12.
    Ruco, L. P. and Meltzer, M.S. (1978). Macrophage activation for tumor cytotoxicity: increased lymphokine responsiveness of peritoneal macrophages during acute inflammation. J. Immunol, 120, 1054PubMedGoogle Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • D. Nolibe
    • 1
  • R. Masse
    • 1
  • J. P. Giroud
    • 1
  1. 1.France

Personalised recommendations