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Effect of flurbiprofen on prostaglandin synthesis (Abstract)

  • V. Kassis
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

The inhibitory effect of topically applied flurbiprofen, a newer non-steroidal anti-inflammatory agent, on prostaglandin biosynthesis in human skin biopsies in primary irritant dermatitis was examined. The flurbiprofen treated areas synthesized significantly less PGE1 (279 pg/mg dry weight) than placebo treated inflamed skin (626 pg/mg dry weight). The average inhibition in 11 treated patients was 55% (p < 0.01 using Wilcoxon’s signed rank test). Furthermore, when the anti-inflammatory effect of flurbiprofen was clinically evaluated, a poor correlation was found between the reduction of prostaglandin synthesis and the clinical effects of flurbiprofen.

Keywords

Public Health Clinical Effect Signed Rank Test Skin Biopsy Poor Correlation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • V. Kassis
    • 1
  1. 1.Denmark

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