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Regulatory mediators in Arthus reactions: lysosomal enzymes in biopsy and serum

  • K. M. Debatin
  • D. Gemsa
  • G. Till
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

The accumulation of polymorphonuclear leukocytes (PMN) has been demonstrated as a central pathogenic event in inflammatory lesions like the Arthus reaction1. During the last decade, the possible role of these cells in acute inflammatory processes has been studied extensively in vitro. As a main focus of these investigations it has become clear that PMN, whenever they encounter immunological stimuli like immune complexes or C5a, release their granule constituents2, 3. The various hydrolytic enzymes stored within different granules take part in the cellular bactericidal systems as well as in the digestion of ingested material (bacteria, immune complexes). However, they have also been demonstrated to degrade a wide variety of tissue substrates in vitro (for review see reference 3). Therefore, the release of proteolytic activities could be an important contribution to the injury which occurs in the inflamed tissue in vivo.

Keywords

Normal Skin Neutral Protease Regulatory Mediator Elastase Activity Human Polymorphonuclear Leukocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • K. M. Debatin
    • 1
  • D. Gemsa
    • 1
  • G. Till
    • 1
  1. 1.West Germany

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