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Experimental protoporphyria in hairless mice: photohaemolysis versus Photodermatitis

  • R. A. Woutersen
  • C. W. M. Van Holsteijn
  • H. Baart De La Faille
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

In 1908 Hausmann1 proved that systemically administered haematoporphyrin might be fatal for mice if they were exposed to violet light, while a much larger dose of this substance was harmless if the animals were kept in the dark. Meyer-Betz2 injected himself with haematoporphyrin which resulted in marked erythema and oedema of the light exposed parts of the body. In spite of this recognized relation between porphyrins and photosensitivity the pathogenesis of the dermatitis of patients who suffer from photosensitive porphyria is not fully understood.

Keywords

Singlet Oxygen Butylate Hydroxy Toluene Active Oxygen Species Hairless Mouse Erythrocyte Suspension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • R. A. Woutersen
    • 1
  • C. W. M. Van Holsteijn
    • 1
  • H. Baart De La Faille
    • 1
  1. 1.Netherlands

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