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RES impairment in NZB/W mice

  • Y-H. Chang
  • C. M. Pearson
  • D. Chia
  • K. R. Aoki
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

NZBAV mice develop a murine lupus very similar to human systemic lupus erythematosus (SLE). The pathogenesis of both diseases remains poorly understood. There is, however, extensive evidence that antigen-antibody complexes play a central role1,2. Much of the tissue damage in these diseases appear to result from deposition of immune complexes in the kidney and other tissue3,4 and the attendant initiation of inflammatory events. Tissue localization may occur from a failure to clear immune complexes from the circulation due to (1) an excessive rate of antibody production and the consequent overloading of the reticuloendothelial system (RES), (2) a subnormal rate of catabolic removal of immune complexes due to impaired RES function, or (3) a combination of these two phenomena. Investigations in the past have placed much emphasis on the hyperactivity of autoantibody production whereas possible impairment of the disposal system for the immune complexes has not received due attention. This investigation was conducted to ascertain whether an impairment in the disposal of soluble immune complexes underlies, or at least contributes to, the pathogenesis of murine lupus in NZB/W mice.

Keywords

Systemic Lupus Erythematosus Immune Complex Peritoneal Macrophage Swiss Webster Mouse Murine Lupus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Goldblum, R., Pillarisetty, R. and Talal, N. (1975). Independent appearance of antithy-mocyte and anti-RNA antibodies in NZB/NZW Fl mice. Immunology, 28, 621Google Scholar
  2. 2.
    Cochrane, C. G. and Koffler, D. (1973). Immune complex disease in experimental animals and man. Adv. Immunol., 16, 185PubMedCrossRefGoogle Scholar
  3. 3.
    Baldwin, D.S., Lowenstein, J., Rothfield, N., Gallo, G. A. and McCluskey, R. (1970). The clinical course of the proliferative and membranous forms of lupus nephritis. Ann. Intern. Med., 73,929PubMedGoogle Scholar
  4. 4.
    Cooke, T. D., Hurd, E. C., Jasin, H. E., Bienenstock, J. and Ziff, M. (1975). Identification of immunoglobulins and complement in rheumatoid articular collagenous tissue. Arthritis Rheum., 18, 541PubMedCrossRefGoogle Scholar
  5. 5.
    McConahey, P. J. and Dixon, F. J. (1966). A method of trace iodination of protein for in vivo studies. Int. Arch. Allergy Appi. Immunol., 29,185CrossRefGoogle Scholar
  6. 6.
    Cochrane, C. G. and Hawkins D. (1968). Studies of circulating immune complexes. III. Factors governing the ability of circulating complexes to localize in blood vessels. J. Exp. Med., 127,137PubMedCrossRefGoogle Scholar
  7. 7.
    Kunkel, H.G., Muller-Eberhard, H. J., Fudenberg, H. H. and Tomase, T.B. (1961). Gamma globulin complexed in rheumatoid arthritis and certain other conditions. J. Clin. Invest., 40,117PubMedCrossRefGoogle Scholar
  8. 8.
    Morgan, A. G. and Steward, M.W. (1976). Macrophage clearance function and immune complex disease in New Zealand Black White F, hybrid mice. Clin. Exp. Immunol., 26,133PubMedGoogle Scholar
  9. 9.
    Christian, C. L. (1960). Studies of aggregated gammaglobulin I. Sedimentation, electropho-retic and anticomplementary properties. J. Immunol., 84,112PubMedGoogle Scholar
  10. 10.
    Kijlstra, A., Knutson, D. W., Daha, H.R. and van Es, L. A. (1977). Glomerular localization of preformed immune complexes. Abstract presented at the Spring Meeting of the British Society for Immunology, April 1977Google Scholar
  11. 11.
    Shinomiya, T. and Koyama, J. (1976). In vitro uptake and digestion of immune complexes containing guinea-pig IgG, and IgG2 anti-bodies by macrophages. Immunology, 30, 267PubMedGoogle Scholar
  12. 12.
    Benacerraf, B., Biozzi, G., Halpern, B. N., Stiffel, C. and Mouton, D. (1957). Phagocytosis of heat denatured human serum albumin labeled with 131I and its use as a means of investigating liver blood flow. Br. J. Exp. Pathol.,38, 35PubMedGoogle Scholar
  13. 13.
    Chia, D., Dorsch, C., Barnett, E. V. and Levy, L. (1977). Metabolism of exogenous single strand of DNA in normal and NZB/W mice. Immunology, 32, 351PubMedGoogle Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • Y-H. Chang
    • 1
  • C. M. Pearson
    • 1
  • D. Chia
    • 1
  • K. R. Aoki
    • 1
  1. 1.USA

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