Activation of complement by metal compounds that induce chronic granulomatous inflammation

  • V. D. Ramanathan
  • P. Badenoch-Jones
  • J. L. Turk
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)


A number of compounds that are known to induce chronic granulomatous inflammation have been shown to activate the complement system1. In a previous report from this laboratory2, certain aluminium and zirconium compounds that are known to induce chronic granulomas were shown to activate complement. It was found that these compounds were able to consume total haemolytic complement, generate anaphylatoxins and split C3 in normal human serum independent of the formation of the classical and the alternative pathway convertases. Furthermore, some of the compounds were shown to be dependent on plasminogen to activate the complement system. The mechanics of this complement activation were further investigated and the relevance of these findings to the induction of granulomas will be discussed in this communication.


Metal Compound Normal Human Serum Zirconium Hydroxide Zirconium Compound Hageman Factor 
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  1. 1.
    Schorlemmer, H. U., Bitter-Suermann, D. and Allison, A. C. (1977). Complement activation by the alternative pathway and macrophage enzyme secretion on the pathogens of chronic inflammation. Immunology, 32,929PubMedGoogle Scholar
  2. 2.
    Ramanathan, V. D., Badenoch-Jones, P. and Turk, J. L. (1979). Complement activation by aluminium and zirconium compounds. Immunology, 37, 881PubMedGoogle Scholar
  3. 3.
    Bitter-Suermann, D., Hadding, U., Melchert, F.and Wellensiek, H. J. (1970).Independent and consecutive action of the complement components C5, C6 and C7 in immune hemolysis-I. Preparation of EAC 1–5 with purified guinea pig C3 and C5. Immunochemistry, 7, 955PubMedCrossRefGoogle Scholar
  4. 4.
    Brade, V., Lee, G. D., Nicholson, A., Shin, H. S. and Mayer, M. M. (1973). The reaction of zymosan with the properdin system in normal and C4-deficient guinea pig serum. J. Immunol, 111, 1389PubMedGoogle Scholar
  5. 5.
    Hudson, L. and Hay, F. C. (1976). Practical Immunology, 1st Edn., p. 139. (London: Black-well Scientific)Google Scholar
  6. 6.
    Hamuro, J., Hadding, U. and Bitter-Suermann, D. (1978). Solid-phase activation of alternative pathway of complement by ß-1,3 glucans and its possible role for tumour regressing activity. Immunology, 34, 695PubMedGoogle Scholar
  7. 7.
    Bitter-Suermann, D., Hadding, U., Schorlemmer, H.U., Limbert, H., Dierich, M. and Dukor, P. (1975). Activation by some T-independent antigens and B cell mitogens of the alternative of the complement system. J. Immunol., 115, 425PubMedGoogle Scholar
  8. 8.
    Lachmann, P. J. (1975). Complement. In Gell, R. R. A., Coombs and Lachmann P. J. (eds.) Clinical Aspects of Immunology, 3rd Edn., p. 333. (London: Blackwell Scientific)Google Scholar
  9. 9.
    Ramanathan, V. D. (1980). Activation of complement by agents inducing chronic granulomatous inflammation. Ph. D. thesis. University of LondonGoogle Scholar
  10. 10.
    Badenoch-Jones, P., Turk, J. L. and Parker, D. (1978). The effects of some aluminium and zirconium compounds on guinea pig peritoneal macrophages and skin fibroblasts in culture. J. Pathol., 124, 51PubMedCrossRefGoogle Scholar
  11. 11.
    Lord, G. H. and Wilson, J. E. (1968). J. Am. Vet. Med. Assoc, 153, 910PubMedGoogle Scholar
  12. 12.
    Turk, J. L. and Parker, D. (1977). Granuloma formation in normal guinea pigs injected intra-dermally with aluminium and zirconium compounds. J. Invest. Dermatol, 68, 336PubMedCrossRefGoogle Scholar
  13. 13.
    Turk, J. L. and Parker, D. (1977). Sensitization with Cr. Ni and Zr salts and allergic type granuloma formation in the guinea pig. J. Invest Dermatol, 68, 341PubMedCrossRefGoogle Scholar
  14. 14.
    Ogston, D., Ogston, O. M., Ratnoff, D. and Forbes, C. D. (1969). J. Clin. Invest., 48,1786PubMedCrossRefGoogle Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • V. D. Ramanathan
    • 1
  • P. Badenoch-Jones
    • 1
  • J. L. Turk
    • 1
  1. 1.UK

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