Activation of complement by metal compounds that induce chronic granulomatous inflammation
A number of compounds that are known to induce chronic granulomatous inflammation have been shown to activate the complement system1. In a previous report from this laboratory2, certain aluminium and zirconium compounds that are known to induce chronic granulomas were shown to activate complement. It was found that these compounds were able to consume total haemolytic complement, generate anaphylatoxins and split C3 in normal human serum independent of the formation of the classical and the alternative pathway convertases. Furthermore, some of the compounds were shown to be dependent on plasminogen to activate the complement system. The mechanics of this complement activation were further investigated and the relevance of these findings to the induction of granulomas will be discussed in this communication.
KeywordsMetal Compound Normal Human Serum Zirconium Hydroxide Zirconium Compound Hageman Factor
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