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Macrophage activation by Listeria-specific T cell sub-populations (Abstract)

  • S. H. E. Kaufmann
  • M. M. Simon
  • H. Hahn
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

Specific interaction of inflammatory T cells with intracellular bacteria (or bacterial antigens) and macrophages in vivo results in macrophage activation and granuloma formation, parallelled by delayed-type hypersensitivity reactions. Using the listeriosis model in mice, we have studied the Lyt phe-notype(s) of inflammatory T cells involved in macrophage activation both in vitro and in vivo. Specific inflammatory T cells from Listeria-infected mice were purified on nylon wool columns and selected for sub-populations by treatment with anti-Lyt antisera and complement. Inflammatory T cells involved in protection to Listeria organisms and in delayed-type hypersensitivity to Hsterial antigens were of the Lyt 123 phenotype. Participation of other Lyt T cell sub-sets in vivo could not be ruled out. In vitro interaction of Listeria-specific inflammatory T cells with listerial antigen and macrophages resulted in macrophage activation, as assessed by the production of myogenic protein. These in vitro data indicate that macrophage activation is accomplished by Lyt 1 T cells rather than Lyt 123 T cells. However, participation of Lyt 123 T cells appears likely.

Keywords

Public Health Hypersensitivity Reaction Specific Interaction Macrophage Activation Press Limited 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • S. H. E. Kaufmann
    • 1
  • M. M. Simon
    • 1
  • H. Hahn
    • 1
  1. 1.W. Germany

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