Serum and synovial fluid ferritin in rheumatoid arthritis

  • D. R. Blake
  • E. J. Eastham
  • M. Thompson
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)


Anaemia commonly follows any chronic inflammatory condition. The causes are complex and centred around alterations in iron kinetics1,2. In patients with rheumatoid arthritis, studies using 59Fe-labelled transferrin suggest that intravenously injected iron is utilized in a normal manner and incorporated into circulating erythrocytes3. However, in chronic inflammatory states, defective utilization of iron from senescent erythrocytes has been shown using 59Fe-labelled cells4 and studies with 59Fe-labelled dextran implicates reticuloendothelial cell dysfunction as the cause5. The excess iron stored within the RE cell is reflected by a rise in the serum ferritin.


Rheumatoid Arthritis Synovial Fluid Serum Ferritin Ferritin Level Serum Ferritin Level 
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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • D. R. Blake
    • 1
  • E. J. Eastham
    • 1
  • M. Thompson
    • 1
  1. 1.UK

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