The effect of therapeutic agents on serum copper levels and serum oxidase activities in the rat adjuvant model compared to analogous results from studies of rheumatoid arthritis in humans
Among the many biochemical changes observed in rheumatoid arthritis and other inflammatory disorders has been a pronounced elevation in serum copper1–3. A similar rise in serum copper has also been observed in the adjuvant arthritic rat4–7. Since ceruloplasmin is the major copper-carrying protein in serum, it seemed likely that there should be a relationship between total serum copper and ceruloplasmin in the diseased and normal states. Recent studies would support this8,9, but there are also claims that non-ceruloplasmin copper may be the major source of additional copper in rheumatoid arthritis3,10. Furthermore, in studies of cancer in animals, the ratio of the amount to the activity of ceruloplasmin, the main oxidase in serum, varies with the severity of the disease11. We decided to investigate the copper-ceruloplasmin relationship in adjuvant arthritis in the rat and to relate this to copper levels in patients with rheumatoid arthritis and normal human controls. These studies were intended to give some insight into the activity of serum copper as well as the amount of the copper and consequently the relationship of these parameters to drug therapies was also studied.
KeywordsRheumatoid Arthritis Copper Level Adjuvant Arthritis Cuprous Oxide Serum Copper
Unable to display preview. Download preview PDF.
- 7.Lewis, A.J., Cottney,J., TeapeJ., Dunlop,J., Smith, W. E. and Brown,D.H. (1980). Copper and its involvement in the inflammatory process. Eur. J. Rheumatol. Inflamm. (In press)Google Scholar
- 14.Lewis, A., Brown, D. H., Dunlop, J. and Smith, W. E. (unpublished results)Google Scholar
- 15.Dunlop, J. and Hazelton, R. (unpublished results)Google Scholar
- 18.Frieden, E. and McKee, D. J. (1971). Binding oftransition metalions by ceruloplasmin. Biochemistry, 10,3880Google Scholar
- 19.Brown, D.H., Dunlop, J., Smith, W.E., Teape, J., Cottney, J. and Lewis, A.J. (1979). Copper distribution following administration of cuprous oxide to rats and guinea pigs. Agents Actions, 9,Google Scholar
- 20.Blake, D. R., Eastham, E. J., and Thomson, M. (1980). Serum and synovial fluid ferritin in rheumatoid arthritis. This volume, Chap. 67Google Scholar