Effect of drugs on serum copper and its correlation with other humoral factors in rheumatoid arthritis

  • M. Cutolo
  • S. Rovida
  • E. Samanta
  • S. Accardo
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)


It was decided to study serum copper levels (sCu) in patients with rheumatoid arthritis (RA) in the light of accumulating experience of an abnormal copper metabolism in rheumatoid arthritis as well as other diseases 4, 8,11,12,18, 20, 24.


Rheumatoid Arthritis Erythrocyte Sedimentation Rate Rheumatoid Arthritis Patient Healthy Control Group Serum Copper 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Amos, R.S., Crockson, R. A., Crockson, A.P., Walsch, L. and McConkey, B., (1978). Rheumatoid arthritis: C-reactive protein and erythrocyte sedimentation rate during initial treatment. Br. Med. J., 1,1936Google Scholar
  2. 2.
    Brown, D.H., Buehan, W.W., El-Gobary, A.F., Smith, W.E. and Teape,J. (1979). Serum copper and its relationship to clinical symptoms in R.A. Ann. Rheum. Dis., 38,174PubMedCrossRefGoogle Scholar
  3. 3.
    Constable, T. J., Crockson, R. A., Crockson, A. P. and McConkey, B. (1975). Lancet, 1, 1176PubMedCrossRefGoogle Scholar
  4. 4.
    Dresch, C., Nayean, Y., Bouchet, J. and Bernard, J. (1972). Anomalies hematologiques des polyarthrites chroniques évolutives. Nouv. Presse Med. 1,163PubMedGoogle Scholar
  5. 5.
    Fridovich, I. (1970). Superoxide dismutase. Ann. Rev. Biochem., 44,147CrossRefGoogle Scholar
  6. 6.
    Frieden, E. (1973). The ferrous to ferric cycles in iron metabolism. Nutr. Rev. 31, 41PubMedCrossRefGoogle Scholar
  7. 7.
    Harper, H. A. (1977). Review of Physiologic Chemistry. (Los Altos Cal. Medical Publications)Google Scholar
  8. 8.
    Hyrgovic, M., Tessmer, C. F., Thomas, E. B., Fuller, L. M., Gamble, J. F. and Shullerm-berger, C. C. (1974). Significance of serum copper levels in adult patient with Hodgkin’s disease. Scand. J. Haematol. 1, 63Google Scholar
  9. 9.
    Jayson, M.I. V., Davies, P., Whicher, J.T. and Walkers, G. (1976). Serum copper and caeruloplasmin in ankylosing spondylitis, systemic sclerosis and morphea. Ann. Rheum. Dis., 35, 443CrossRefGoogle Scholar
  10. 10.
    Aeseth, J., Munthe, A., Farre, O. and Steinnes E. (1978). Trace elements in serum and urine of patients with rheumatoid arthritis. Scand. J. Rheumatol., 7,237CrossRefGoogle Scholar
  11. 11.
    Jensen, K. B., Thorling, E. B. and Anderson, C. J. (1964). Serum copper in Hodgkin’s diseases. Scand. J. Haematol. 1, 63PubMedCrossRefGoogle Scholar
  12. 12.
    Kolaric, K., Roguljic, A. and Fuss, V. (1975). Serum copper levels in patients with solid tumors. Tumori, 61,173PubMedGoogle Scholar
  13. 13.
    Koskelo, P., Kekki, M., Virkkunem, M., Lasus, A. and Somer, T. (1969). Serum caeruloplasmin concentration in RA, ankylosing spondylitis, psoriasis and sarcoidosis. Acta Rheum. Scand. 12, 261Google Scholar
  14. 14.
    Marcel, E. Nimni (1979). Penicillamine and collagen metabolism. Scand. J. Rheumatol. Suppl., 28, 71Google Scholar
  15. 15.
    Munthe, E., Jellum, E. and Aeseth, J. (1979). Some aspects of the mechanism of action of Penicillamine in RA. Scand. J. Rheumatol. 128, 6CrossRefGoogle Scholar
  16. 16.
    Munthe, E. (1976). Penicillamine Research and Rheumatoid Diseases, p. 198 (Oslo: Fabritius & Sønner) Google Scholar
  17. 17.
    Osaki, S., Johnson, D. A. and Frieden, E. (1966). The possible significance of the ferrous oxidase activity of caeruloplasmin in normal human serum. J. Biol. Chem. 241, 2746PubMedGoogle Scholar
  18. 18.
    Scudder P.R., Al-Timini, D., McMurray, W., White, A. G., Zoob, B.C., and Dor-mandy, T. L. (1978). Serum copper and related variables in Rheumatoid Arthritis. Ann. Rheum. Dis. 37, 67PubMedCrossRefGoogle Scholar
  19. 19.
    Scudder, P.R. McMurray, W., White, A. G. and Dormandy, T. L. (1978). Synovial fluid copper and related variables in rheumatoid and degenerative arthritis. Ann. Rheum. Dis. 37, 71PubMedCrossRefGoogle Scholar
  20. 20.
    Sinha, S.N. and Gabrieli, E. R. (1970). Serum copper and zinc levels in various pathologic conditions. Am. J. Clin. Pathol. 54, 570PubMedGoogle Scholar
  21. 21.
    Sorenson, J.R. J. (1976).J. Med. Chem. 19,135PubMedCrossRefGoogle Scholar
  22. 22.
    Smallwood, R. A., Williams, H. A. Rosenoer, V. M. and Sherlock, K. S.: Lancet, 1203Google Scholar
  23. 23.
    Sternlich, I., Sandson, J.I., Morell, A.G., Korotkin, E. and Sheinberg J. (1978). Non-caeruloplasmin copper in RA. Arthritis Rheum. 12, 458CrossRefGoogle Scholar
  24. 24.
    Tanner, H. S. et al. (1979). Increased hepatic copper concentration in Indian Childhood Cirrhosis. Lancet, 1203Google Scholar
  25. 25.
    Todd, Sanford, Davidsohn (1979). Clinical diagnosis and management by laboratory methods, 298Google Scholar
  26. 26.
    Walsh, H. A., Davies, P. and McConkey, B. (1979). Relationship between ESR and CRP in RA. Ann. Rheum. Dis. 38, 362PubMedCrossRefGoogle Scholar
  27. 27.
    Williams, D. R. (1971). The metals of life: the solution chemistry of metal ions in biological systems. London VNRGoogle Scholar
  28. 28.
    Oriente, P., Scarpa, R., Cutolo, M., Riccio, A. and Pucino, A. (1980). Serum copper and d2-ceruloplasmin as further index of inflammation. International Symposium on Rheumatoid Arthritis, Verona. Abstract 15Google Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • M. Cutolo
    • 1
  • S. Rovida
    • 1
  • E. Samanta
    • 1
  • S. Accardo
    • 1
  1. 1.Italy

Personalised recommendations