Modification of Chemotaxis and peptide binding during pathophysiological state of polymorphonuclear leukocytes

  • M. Roch-Arveiller
  • J. P. Abita
  • D. Bradshaw
  • J. P. Giroud
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)


Local recruitment of polymorphonuclear leukocytes (PMNs) to inflammatory sites is essential to the host in its defence against injury. The activation of directed migration of cells (Chemotaxis) along a chemical gradient is determined by a variety of attractants such as serum factors1, particularly a fragment of the fifth component of complement2, bacterial metabolites3, cell derived materials from sensitized lymphocytes4, or PMNs and denatured proteins5. Recently Schiffman et al. 6 have shown that small synthetic N-formyl-methionyl peptides, which may be related to natural bacterial leukoattractants, induce leukocyte Chemotaxis. Williams et al. 7 with human PMNs and Aswanikumar et al. 8, with rabbit PMNs have demonstrated that membrane receptors appear to mediate Chemotaxis induced by both natural bacterial peptides and formylated synthetic peptides.


Migration Inhibitory Factor Peptide Binding Boyden Chamber Human Polymorphonuclear Leukocyte Calcium Pyrophosphate 
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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • M. Roch-Arveiller
    • 1
  • J. P. Abita
    • 1
  • D. Bradshaw
    • 1
  • J. P. Giroud
    • 1
  1. 1.France

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