Monosodium urate monohydrate stimulates release of lysosomal enzymes and prostaglandins from macrophages

  • R. M. McMillan
  • P. Hasselbacher
  • Edward D. HarrisJr
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)


Ingestion of monosodium urate monohydrate (MSUM) crystals causes release of lysosomal and cytoplasmic enzymes from polymorphonuclear leukocytes1,2. These processes are well characterized and are believed to mediate many manifestations of acute gout3. In contrast, the mechanisms of tissue destruction in chronic gouty arthritis are poorly understood and there is little information about the interaction of MSUM with chronic inflammatory cells such as mononuclear phagocytes.


Lysosomal Enzyme Mononuclear Phagocyte Phorbol Myristate Acetate Enzyme Release Mouse Peritoneal Macrophage 
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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • R. M. McMillan
    • 1
  • P. Hasselbacher
    • 1
  • Edward D. HarrisJr
  1. 1.USA

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