Advertisement

Monosodium urate monohydrate stimulates release of lysosomal enzymes and prostaglandins from macrophages

  • R. M. McMillan
  • P. Hasselbacher
  • Edward D. HarrisJr
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

Ingestion of monosodium urate monohydrate (MSUM) crystals causes release of lysosomal and cytoplasmic enzymes from polymorphonuclear leukocytes1,2. These processes are well characterized and are believed to mediate many manifestations of acute gout3. In contrast, the mechanisms of tissue destruction in chronic gouty arthritis are poorly understood and there is little information about the interaction of MSUM with chronic inflammatory cells such as mononuclear phagocytes.

Keywords

Lysosomal Enzyme Mononuclear Phagocyte Phorbol Myristate Acetate Enzyme Release Mouse Peritoneal Macrophage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Shirahama, T. and Cohen, A. S. (1974). Ultrastructural evidence for leakage of lysosomal contents after phagocytosis of monosodium urate crystals. Am. J. Clin. Pathol., 76, 501Google Scholar
  2. 2.
    Hoffstein, S. and Weissmann, G. (1975). Mechanisms of monosodium urate crystals with dog, fish and human leukocytes. Arthritis Rheum, 18, 153PubMedCrossRefGoogle Scholar
  3. 3.
    Weissmann, G. (1971). The molecular basis of acute gout. Hosp. Pract., 6, 43Google Scholar
  4. 4.
    Weissmann, G., Dukor, P. and Zurier, R. B. (1971). Effect of cyclic nucleotides on release of lysosomal enzymes from phagocytes. Nature (London), New Biol., 231, 131Google Scholar
  5. 5.
    Davies, P., Page, R. C. and Allison, A. C. (1974). Changes in cellular enzyme levels and extracellular release of lysosomal acid hydrolases in macrophages exposed to group A streptococcal cell wall substance. J. Exp. Med., 139, 162CrossRefGoogle Scholar
  6. 6.
    Cardella, C. J., Davies, P. and Allison, A. C. (1974). Immune complexes induce selective release of lysosomal hydrolases from macrophages in vitro. Nature (London), 261, 48Google Scholar
  7. 7.
    McMillan, R. M., MacIntyre, D. E., Beesley, J. E. and Gordon, J. L. (1980). Regulation of macrophage lysosomal enzyme release: role of arachidonate metabolites, divalent cations and cyclic AMP. J. Cell. Sci. (In press)Google Scholar
  8. 8.
    Hasselbacher, P. (1979). C3 activation by monosodium urate monohydrate and other crystalline material. Arthritis Rheum., 22, 571PubMedCrossRefGoogle Scholar
  9. 9.
    Brinckerhoff, C.E., McMillan, R.M. Fahye, J. V. and Harris, E.D., Jr. (1979). Collagenase production by synovial fibroblasts treated with phorbol myristate acetate. Arthritis Rheum., 22, 1109PubMedCrossRefGoogle Scholar
  10. 10.
    Schorlemmer, H. U., Ferluga, J. and Allison, A. C. (1977). Interactions of macrophages and complement components in the pathogenesis of chronic inflammation. In Willoughby, D. A., Giroud, J. P., and Velo, G. P., (eds.) Perspectives in Inflammation-Future Trends and Developments., p. 191. (Lancaster: MTP Press)Google Scholar
  11. 11.
    Gordon, J. L., Maclntyre, D. E. and McMillan, R. M. (1977). Stimulation of platelets and macrophages by carrageenin. Br. J. Pharmacol., 61, 140P.Google Scholar
  12. 12.
    Bonney, R.J., Wightman, P.D., Davies, P., Sadowski, S.J., Dahlgren, M.E., Kuehl, F. A., Jr., and Humes, J.L. (1978). Secretion of inflammatory mediators by macrophages as a function of their state of stimulation. J. Cell Biol., 75, 96aGoogle Scholar
  13. 13.
    Bonney, R.J., Wightman, P.D., Davies, P., Sadowski, S. J., Kuehl, F.A., Jr. and Humes, J. L. (1978). Regulation of prostaglandin synthesis and of the selective release of lysosomal hydrolases by mouse peritoneal macrophages. Biochem. J., 176, 433PubMedGoogle Scholar
  14. 14.
    Brune, K., Glatt, M., Kalin, H. and Peskar, B. A. (1978). Pharmacological control of prostaglandin and thromboxane release from macrophages. Nature (London), 274, 261CrossRefGoogle Scholar
  15. 15.
    Fine, I., Wigley, F., Chang, J. and Newcombe, D. (1980). Crystal-induced synthesis of prostaglandin (PG) E2 by macrophages. Proceedings of the 4th International Prostaglandin Conference Google Scholar
  16. 16.
    Fine, I., Sannes, P. and Newcombe, D. (1980). Human synovial fibroblasts and macrophages: urate phagocytosis and prostaglandin release. Clin. Res., 28, 146AGoogle Scholar
  17. 17.
    Kozin, F., Ginsburg, M. H. and Skosey, J.L. (1979). Polymorphonuclear leukocyte responses to monosodium urate crystals: modification by absorbed serum proteins. J. Rheumatol., 6, 519PubMedGoogle Scholar
  18. 18.
    Ginsburg, M., Henson, P., Henson, J. and Kozin, F. (1979). Mechanisms of platelet response to monosodium urate crystals. Am. J. Pathol., 94, 549Google Scholar
  19. 19.
    Hasselbacher, P. (1979). Binding of IgG and complement protein by monosodium urate monohydrate and other crystals. J. Lab. Clin. Med., 94, 532PubMedGoogle Scholar
  20. 20.
    McMillan, R. M:, Hasselbacher, P. and Harris, E. D., Jr. (unpublished data)Google Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • R. M. McMillan
    • 1
  • P. Hasselbacher
    • 1
  • Edward D. HarrisJr
  1. 1.USA

Personalised recommendations