Neutrophil interactions with particulate materials: an in vitro model for inflammatory arthritides
Previous studies by our group1 and others2 have established in vitro systems for examining the interactions between neutrophils and immunoglobulin G aggregates or monosodium urate crystals which may be important in the inflammatory processses occurring in rheumatoid arthritis and gout. The present studies utilize a previously described3 neutrophil monolayer system to quantitate the uptake of these particulate materials along with their subsequent effects on cellular adherence and enzyme release.
KeywordsParticulate Material Enzyme Release Calcium Pyrophosphate Urate Crystal Minute Figure
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