Collagenase release from synovial fibroblasts: relationship to fatty acid release and prostaglandin synthesis
Rheumatoid synovium has proliferative and destructive characteristics in vivo. These capabilities are also evident in tissue culture studies in which cultured expiants of rheumatoid synovium have been shown to invade normal tendon1 and release substances which stimulate bone resorption2. There are numerous biochemical differences between normal and inflamed synovia but it is likely that the destructive capacity of rheumatoid tissues is related in part to formation of high levels of prostaglandins (PGs) and collagenase3,4. PGE2, released from cultured rheumatoid synovium, stimulates bone resorption2 and collagenase is believed to be the major enzyme responsible for cartilage degradation associated with rheumatoid arthritis5,6.
KeywordsSynovial Fibroblast Hank Balance Salt Solution Inflame Synovia Rheumatoid Synovium Stimulate Bone Resorption2
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