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Selective control of formation of 1 and 2 series prostaglandins: a new concept in the regulation of inflammation and immunity

  • D. F. Horrobin
  • M. S. Manku
  • M. Oka
  • S. C. Cunnane
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

The roles of prostaglandins (PGs) and thromboxanes (TXs) in inflammation are uncertain. There can be no doubt that these agents are formed in increased amounts in a wide variety of inflammatory conditions and that inhibition of that formation by steroids and by non-steroidal anti-inflammatory drugs (NSAID) is well correlated with relief of symptoms in both acute and chronic inflammatory conditions in humans and with suppression of some of the features of acute inflammation in animal models. On the other hand, there is equally no doubt that glucocorticoids and NSAID do not favourably influence the long-term course of most chronic inflammatory states in humans1. Furthermore there is a good deal of evidence that PGs can play antiinflammatory roles2–5.

Keywords

Familial Mediterranean Fever Essential Fatty Acid Selective Control Intracellular Calcium Release Cystic Fibrosis46 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • D. F. Horrobin
    • 1
  • M. S. Manku
    • 1
  • M. Oka
    • 1
  • S. C. Cunnane
    • 1
  1. 1.Canada

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