Mechanism of inhibition of prostaglandin biosynthesis by anti-inflammatory steroids
Anti-inflammatory steroids inhibit prostaglandin (PG) biosynthesis in a variety of tissues and cultured cells. This inhibition is secondary to a suppression of phospholipase A2, the enzyme which releases arachidonic acid from membrane phospholipids1,2. Recent reports show that the inhibition of PG biosynthesis and the anti-inflammatory effect of glucocorticosteroids depend on receptor occupancy and require RNA and protein synthesis3–7.
KeywordsArachidonic Acid Krebs Solution Bordetella Pertussis Prostaglandin Biosynthesis Generator Leukocyte
Unable to display preview. Download preview PDF.