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Mechanism of inhibition of prostaglandin biosynthesis by anti-inflammatory steroids

  • M. Di Rosa
  • P. Persico
  • R. Carnuccio
  • A. Pinto
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

Anti-inflammatory steroids inhibit prostaglandin (PG) biosynthesis in a variety of tissues and cultured cells. This inhibition is secondary to a suppression of phospholipase A2, the enzyme which releases arachidonic acid from membrane phospholipids1,2. Recent reports show that the inhibition of PG biosynthesis and the anti-inflammatory effect of glucocorticosteroids depend on receptor occupancy and require RNA and protein synthesis3–7.

Keywords

Arachidonic Acid Krebs Solution Bordetella Pertussis Prostaglandin Biosynthesis Generator Leukocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • M. Di Rosa
    • 1
  • P. Persico
    • 1
  • R. Carnuccio
    • 1
  • A. Pinto
    • 1
  1. 1.Italy

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