Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenin pleural exudates (Abstract)
Aspirin-like drugs inhibit the metabolism of arachidonic acid via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenin pleural exudates. These non-steroidal anti-inflammatory drugs inhibit the formation of 11-hydroxy- and 15-hydroxy-eicosatetraenoic acid (HETE) as well as prostaglandins. In addition, the concentration and time dependent irreversible inhibition of lipoxygenase by aspirin and indomethacin parallels closely the patterns observed for inhibition of cyclo-oxygenase. The results suggest that some common steps may exist for the synthesis of HETE and prostaglandins from arachidonic acid in rat neutrophils. The ability of aspirin-like drugs to inhibit the formation of the chemotactic hydroxy fatty acids may contribute to their anti-inflammatory activity.