Advertisement

Anti-inflammatory actions of an immunomodulator: therafectin 1,2-O-isopropylidene-3-O-3′-(N’, N’-dimethylamino n-propyl)-D-gluco-furanose, HCl

  • P. Gordon
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

Most of the non-steroidal anti-inflammatory agents in clinical use today are substituted aromatic organic acids. These agents are endowed with an unfortunately high incidence of toxicity1 which may have to do with unavoidable unwanted side effects of their powerful influence on that pathway of arachi-donic acid metabolism that leads to prostaglandin synthesis.

Keywords

Drinking Water Adjuvant Arthritis Arachidonic Acid Metabolism Muramyl Dipeptide Peripheral White Blood Cell Count 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Dodge, P. W., Brodic, D. and Mitchell, B. D. (1979). Evaluation of the toxicity of antiinflammatory drugs. In Vane, J. R. and Ferreira, S. H. (eds.) Anti-inflammatory Drugs. Vol. 50/11, Chap. 29, p. 280. Berlin: Springer-Verlag.CrossRefGoogle Scholar
  2. 2.
    Majde, J. A. and Gordon, P. (1976). Immunomodulation by l, 2–2-O-isopropylidene-3-O-3’-(N’N’-dimethyl-amino-n-propyl)-D-glucofuranoseSM-1213, a drug with antiviral activity. In Sixteenth Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract, Chicago, IllinoisGoogle Scholar
  3. 3.
    Files, Greenwich Pharmaceuticals Incorporated. 95 East Putnam Avenue, Greenwich, Connecticut, 06830Google Scholar
  4. 4.
    Hadden, J.W., Englard, A., Sadlik, J.R., and Hadden, E.M. (1979). The comparative effects of Isoprinosine, Levamisole, Muramyl Dipeptide, and SM-1213 on lymphocyte and macrophage proliferation and activation in vitro. Int. J. Immunopharmacol., 1, 17PubMedCrossRefGoogle Scholar
  5. 5.
    Goldlust, M. G., Rich, L. C., and Brown, W. R. (1978). Immune synovitis in rabbits: Effects of differing schedules for intra-articular challenge with antigen. Am. J. Pathol., 91, 329PubMedGoogle Scholar
  6. 6.
    di Rosa, M., Papadimitriou, J. M., Willoughby, D. A. (1971). A histopathological and pharmacological analysis of the mode of action of nonsteroidal anti-inflammatory drugs. J. Pathol., 105, 239PubMedCrossRefGoogle Scholar
  7. 7.
    Pearson, C. M. and Wood, F. E. (1959). Studies of polyarthritis and other lesions induced in rats by injection of Mycobacterial adjuvant. I. General clinical and pathologic characteristics and some modifying factors. Arthritis Rheum., 2, 440CrossRefGoogle Scholar
  8. 8.
    Palmer, R. M. J., Salmon, J. A., Narumiya, S., Higgs, G. A., and Eakins, K. E.(1980). Arachadonic acid metabolism by lipoxygenase in leukocytes of different species and the chemo-kinetic activity of some products. This Volume, Chap. 35Google Scholar
  9. 9.
    Michelson, A.M. (1974). Is singlet oxygen a substrate for superoxide dismutase? No. FEBS Lett. 44, 97PubMedCrossRefGoogle Scholar
  10. 10.
    Ferreira, S. H. and Vane, J. R. (1979). Mode of action of anti-inflammatory agents which are prostaglandin synthetase inhibitors. In Vane, J. R. and Ferreira, S.H. (eds.) Antiinflammatory Drugs. Vol. 50/11, Chap. 31, p. 348. Berlin: Springer-VerlagGoogle Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • P. Gordon
    • 1
  1. 1.USA

Personalised recommendations