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Possible synergism between ovariectomy and oestradiol in preventing Freund’s adjuvant arthritis in the rat

  • A. Sfikakis
  • K. Karamanis
  • Ch. Laiou
  • P. Sfikakis
  • D. Varonos
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

In a previous study1 we noticed that long-term ovariectomy (50–70 days) resulted in (a) a significant increase of the weight of the thymus, both absolute and relative, and (b) in a decrease of the relative adrenal weight when compared to intact rats of similar age. On the other hand, the administration of oestradiol benzoate (300 Mg/kg) for three consecutive days and a three day interval was followed by a significant decrease of the thymus weight, both absolute and relative and an increase of the relative adrenal weight reaching the level of thymus and adrenals found in intact rats.

Keywords

Organ Weight Adjuvant Arthritis Spleen Weight Oestradiol Treatment Adrenal Weight 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • A. Sfikakis
    • 1
  • K. Karamanis
    • 1
  • Ch. Laiou
    • 1
  • P. Sfikakis
    • 1
  • D. Varonos
    • 1
  1. 1.Greece

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