Development of an Arthus-like model of induced inflammation and its use in the anti-inflammatory characterization of orgotein (bovine Cu-Zn superoxide dismutase)
The procedure of Ungar et al. 1 of gravimetrically measuring skin oedema, especially as induced by intradermal injection of anti-serum (reverse Arthus reaction), is a common model for assaying anti-inflammatory activity. We have found that the large number of subjective factors involved in the skin dissection and punching can be controlled by randomly blinding drug dosing and other parameters. However, variations in anti-serum from lot to lot may also influence the results, making it desirable to find a more uniform and less expensive inflammant.
KeywordsIntradermal Injection Average Saline Group Inflammatory Index Arthus Reaction Binding Cell Wall
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