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Effect of irradiation and cell reconstitution on the macrophage mitogenic activity of exudate and inflammatory serum

  • M. Pelletier
  • J. P. Giroud
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

Our recent findings have demonstrated the existence of a mitogenic factor, for macrophages in culture, in acute inflammatory exudates (IMF) and sera of inflamed rats1–3,8,14 which could be formed or released by cells14. The question arises whether the factors present in the exudate and in the serum have the same cellular origin and are identical chemical entities.

Keywords

Mitogenic Activity Newborn Calf Serum Thymic Cell Inflammatory Exudate Liquid Scintillation Spectrometer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Adolphe, M., Fontagne, J., Pelletier, M. and Giroud, J. P. (1975). Induction of DNA synthesis in rat macrophages in vitro by inflammatory exudate. Nature (London), 253, 637CrossRefGoogle Scholar
  2. 2.
    Adolphe, M., Fontagne, J., Pelletier, M., Giroud, J. P., Timsit, J. and Lechat, P. (1976). Induction of DNA synthesis in rat peritoneal macrophages in culture by a pleural inflammatory exudate. Agents Actions, 6, 114PubMedCrossRefGoogle Scholar
  3. 3.
    Adolphe, M., Fontagne, J., Pelletier, M., Blondeion, D., Lechat, P. and Giroud, J. P. (1977). In Willoughby, D. A., Giroud, J. P. and Velo, G. P. eds.) Perspectives in Inflammation, Future Trends and Developments. The Proceedings of the Third International Meeting on Future Trends in Inflammation, p. 469 (Lancaster: MTP Press)Google Scholar
  4. 4.
    Bloom, B.R., (1971). In vitro approaches to the mechanism of cell-mediated immune responses. Adv. Immunol., 13, 101PubMedCrossRefGoogle Scholar
  5. 5.
    David, J. R. and David, R. R. (1972). Cellular hypersensitivity and immunity. Prog. Allergy, 16, 300PubMedCrossRefGoogle Scholar
  6. 6.
    Fidler, I. J., Darnell, J. H. and Budmen, M. B. (1976). In vitro activation of mouse macrophages by rat lymphocyte mediators. J. Immunol., 117, 666PubMedGoogle Scholar
  7. 7.
    Giroud, J. P., Fontagne, J., Blondelon, D., Adolphe, M., Dunn, C. J., Willoughby, D. A. and Lechat, P. (1977). Stimulation of macrophage DNA synthesis in culture by different types of acute non-immunological inflammatory exudates. Biomedicine, 27, 19PubMedGoogle Scholar
  8. 8.
    Giroud, J. P., Pelletier, M., and Girre, C. (1977). Pouvoir mitogene de serums de rats porteurs d’une inflammation aigue vis-à-vis de macrophages en culture. C. R. Acad. Sci., Ser. D, 285, 1143Google Scholar
  9. 9.
    Hadden, J.W., Sadlik, J. R. and Hadden, E. M. (1975). Macrophage proliferation induced in vitro by a lymphocyte factor. Nature (London), 257, 483CrossRefGoogle Scholar
  10. 10.
    Hadden, J. W. and Englard, A. (1977). Molecular aspects of macrophage activation and proliferation. In Hadden, J. W., Goffrey, R. G. and Spreafico, F. (eds). Immunopharmacology. (New York: Plenum)CrossRefGoogle Scholar
  11. 11.
    McGregor, D.D. and Koster, F.T., 1971. The mediator of cellular immunity. IV. Cooperation between lymphocytes and mononuclear phagocytes. Cell. Immunol., 2, 317PubMedCrossRefGoogle Scholar
  12. 12.
    North, R. J. and Mackaness, G. B. (1973). Immunological control of macrophage proliferation in vivo. Infect. Immun., 8, 68PubMedGoogle Scholar
  13. 13.
    Pelletier, M., Girre, C., Dunn, C. J., Willoughby, D. A. and Giroud, J. P: (1978). Induction of macrophage DNA synthesis in vitro by non-immunological inflammatory exudates: effect of irradiation and thymic or bone marrow cell reconstitution. J. Pathol., 126, 95PubMedCrossRefGoogle Scholar
  14. 14.
    Pelletier, M., Girre, C., Lenfant, M., Fontagne, J., Adolphe, M. and Giroud, J.P. (1979). Inflammatory mitogenic factor (IMF): relation with T lymphocytes. Eur. J. Rheumatol. Inflam., 2, 124Google Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • M. Pelletier
    • 1
  • J. P. Giroud
    • 1
  1. 1.France

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