In vivo inhibition of pmn migration by antimacrophage serum
The aim of the present investigation was to evaluate the effect of rabbit anti-rat macrophage serum (AMS) on the oedema and cell migration induced by a preparation of M. tuberculosis. Inflammation induced by M. tuberculosis is known to recruit macrophages, and anti-macrophage serum was found to affect macrophages in vitro as well in vivo, and is becoming a valuable tool to study their various functions1–4.
KeywordsNormal Rabbit Serum Differential White Cell Count Quantitative Morphologic Analysis Macrophage Serum Alarm Cell
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- 2.Hirsh, M. S., Gary, G. W. Jr. and Murphy, F. A. (1969). In vitro and in vivo properties of antimacrophage sera. J. Immunol., 102, 656Google Scholar
- 7.Bøyum, A. (1976). Isolation of lymphocytes, granulocytes and macrophages. Scand. J. Immunol., 5, (Suppl. 5),Google Scholar
- 8.Stuart, A. E., Habeshaw, J. A. and Davidson, E. A. (1978). Phagocytes in vitro. In Weir, D.M. (ed.) Handbook of Experimental Immunology, Vol. 2. Cellular Immunology, pp. 1–30. (Oxford: Blackwell Scientific)Google Scholar
- 10.Wadsworth, A., Maltaner, E. and Maltaner, F. (1931). The quantitative determination of the fixation of complement by the imune serum antigen. J. Immol., 21, 241Google Scholar
- 12.Chalkley, H. W-. (1943). Method for the quantitative morphologic analysis of tissues. J. Natl. Cancer Inst., 4, 47Google Scholar
- 17.Kazmierowski, J. A., Gallin, J. I. and Reynolds, H. Y. (1977). Mechanism for the inflammatory responses in primate lungs. Demonstration and partial characterization of an alveolar macrophage-derived chemotactic factor with preferential activity for polymorphonuclear. J. Clin. Invest., 59, 273PubMedCrossRefGoogle Scholar