Influence of regional blood flow and inflammation on the localization of lymphoblasts in the small intestine of the mouse
The ability of effector lymphocytes (lymphoblasts and their progeny) to act in a given tissue depends upon their localization within that tissue. Effector cells generated in lymphoid tissue in response to antigenic stimulation make their way to non-lymphoid tissue via the blood stream. Peripherally induced blasts, especially of the T cell line, have been found to have a propensity to localize in regions of inflammatory injury1. There is also a large body of evidence which indicates that, even in the absence of overt inflammation, there is a continuous repopulation of the gut tract with large numbers of both T and B lymphoblasts2–6. This is achieved by the deployment of effector lymphocytes which have arisen in Peyer’s patches and mesenteric lymph nodes and have travelled by way of the thoracic duct and the blood stream to return to the gut.
KeywordsCardiac Output Small Intestine Mesenteric Lymph Node Blast Cell Thoracic Duct
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