T lymphocyte sub-populations in rheumatoid arthritis
A variety of immunopathological findings indicate the involvement of the immune system in rheumatoid arthritis (RA), a disease of unknown origin. The finding of large numbers of T cells in the inflamed rheumatoid synovium1,2 and the effect of T cell depletion by ductus thoracicus drainage during the course of the disease3 suggests a role of the T lymphocyte in the pathogenesis of the disease. Recently human T lymphocytes have been classified4 into two sub-populations with regard to the presence of receptors for immunoglobulin M or G. T lymphocytes with receptors for IgM (Tμ) contain a population of cells capable of enhancing immunoglubulin (Ig) synthesis by PWM stimulated B lymphocytes, whereas T cells with receptors for IgG (Tγ) can suppress Ig synthesis in the same assay.
KeywordsRheumatoid Arthritis Rheumatoid Arthritis Patient Juvenile Rheumatoid Arthritis Progressive Systemic Sclerosis Rheumatoid Arthritis Serum
Unable to display preview. Download preview PDF.
- 1.Bovel, J. A. van and Paget, S. A. (1875). Predominantly T cell infiltrate in rheumatoid synovial membranes. N. Engl. J. Med., 293, 517Google Scholar
- 7.Borel, Y., Strelkaukas, A. J. Calley, R. T. and Schlossman, S. F. (1979). AntiTcellantibody and loss of suppressor T cell in juvenile rheumatoid arthritis. Arthritis Rheum., 23, 595Google Scholar