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Centrally-Administered Bombesin Delays Small Intestinal Transit but Stimulates Motility in the Rat

  • F. Porreca
  • J. T. Fulginiti
  • T. F. Burks

Abstract

The concept of centrally-mediated effects on gastrointestinal motility has recently become established (1). Our laboratory has reported that bombesin, a neuropeptide localized in both the central nervous system and gastrointestinal tract of mammals (2,3), effectively reduces gastric emptying and small bowel transit after intracerebroventricular (i.c.v.) administration to rats (4). Similarly, morphine and the opioid peptides produce dramatic slowing effects on gastrointestinal transit after central administration (5).

Keywords

Gastric Emptying Gastrointestinal Motility Opioid Peptide Intestinal Motility Small Intestinal Transit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Burks, T.F. (1978). Central sites of action of gastrointestinal drugs. Gastroenterology, 74, 332–324Google Scholar
  2. 2.
    Villarreal, J., Brown, M. (1978). Bombesin-like peptide in hypothalamus: chemical and immunological characterization. Life Sci., 23, 2729–2733PubMedCrossRefGoogle Scholar
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    Porreca, F. and Burks, T.F. (1983). Centrally administered bombesin affects gastric emptying and small and large bowel transit in the rat. Gastroenterology, 85, 313–317PubMedGoogle Scholar
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    Galligan, J.J. and Burks, T.F. (1982). Opioid peptides inhibit intestinal transit in the rat by a central mechanism. Eur. J. Pharmacol., 85, 61–68PubMedCrossRefGoogle Scholar
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    Galligan, J.J. and Burks, T.F. (1983). Centrally mediated inhibition of small intestinal transit and motility by morphine in the rat. J. Pharmacol. Exp. Ther., 226, 356–361PubMedGoogle Scholar
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    Taché, Y. and Brown, M. (1982). On the role of bombesin in homeostasis. Trends Neurosci., 5, 431–433.CrossRefGoogle Scholar

Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • F. Porreca
  • J. T. Fulginiti
  • T. F. Burks

There are no affiliations available

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