Advertisement

Spinal, Supraspinal and Peripheral Sites of Opioid Intestinal Actions

  • T. F. Burks
  • J. J. Galligan
  • L. D. Hirning
  • F. Porreca

Abstract

Opioid agonists, administered systemically, induce profound changes in gastrointestinal contractile and propulsive activity. It has now become apparent that opioids can exert effects at multiple sites within the body with different intestinal motility consequences. Also, the recognition of multiple subtypes of opioid receptors and the multiplicity of receptor actions of individual opioid agonists has recently provided new tools for the identification of sites and mechanisms of opioid actions affecting motility (1,2). It was our purpose to explore systematically the roles of brain, spinal cord, intramural neuron and smooth muscle components of opioid actions that influence gastrointestinal motility.

Keywords

Opioid Receptor Gastrointestinal Motility Intestinal Transit Opioid Agonist Delta Opioid Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Martin, W.R., Eades, C.G., Thompson, J.A., Huppler, R.E. and Gilbert, P.E. (1976). The effects of morphine and nalorphine-like drugs in the non-dependent and morphine-dependent chronic spinal dog. J. Pharmacol. Exp. Ther., 197, 517–523PubMedGoogle Scholar
  2. 2.
    Lord, J.A.H., Waterfield, A.A., Hughes, J. and Kosterlitz, H.W. (1977). Endogenous opioid peptides: multiple agonists and antagonists. Nature, 267: 495–499PubMedCrossRefGoogle Scholar
  3. 3.
    Nanda, B.K., Lane, A.C., Lord, J.A.H., Morgan, B.A., Rance, M.J. and Smith, C.F.C. (1981). Analogues of 8-LPH61–64 possessing selective agonist activity at 0-opiate receptors. Eur. J. Pharmacol., 70: 531–540CrossRefGoogle Scholar
  4. 4.
    Chang, K.-J., Cuatrecasas, P., Wei. E.T. and Chang, J.-K (1982). Analgesic activity of intracerebroventricular administration of morphiceptin and ß-casomorphins: correlation with the morphine (p) receptor binding affinity. Life Sci., 30: 1547–1551PubMedCrossRefGoogle Scholar
  5. 5.
    Von Voightlander, P.H., Lahti, R.A. and Ludens, J.H. (1983). A selective and structurally novel non-mu (kappa) opioid agonist. J. Pharmacol. Exp. Ther., 224, 7–12Google Scholar
  6. 6.
    Mosberg, H.I., Hurst, R., Hruby, V.J., Gee, K., Yamamura, H.I., Galligan, J.J. and Burks, T.F. (1983). Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors. Proc. Natl. Acad. Sci. USAGoogle Scholar
  7. 7.
    Galligan, J.J. and Burks, T.F. (1983). Centrally mediated inhibition of small intestinal transit and motility by morphine in the rat. J. Pharmacol. Exp. Ther., 226, 356–361PubMedGoogle Scholar
  8. 8.
    Miller, M.S., Galligan, J.J. and Burks, T.F. (1981). Accurate measurement of intestinal transit. J. Pharmacol. Methods, 6, 211–217PubMedCrossRefGoogle Scholar
  9. 9.
    Haley, T.J. and McCormick, W.G. (1957). Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br. J. Pharmacol., 12, 12–15Google Scholar
  10. 10.
    Hylden, J.L.K. and Wilcox, G.L. (1980). Intrathecal morphine in mice: a new technique. Eur. J. Pharmacol., 67, 313–316PubMedCrossRefGoogle Scholar
  11. 11.
    Burks, T.F. (1974). Vascularly perfused isolated intestine. Proc. Fourth Intl. Symp. Gastrointestinal Motility, pp. 649–656. ( Vancouver: Mitchell Press )Google Scholar
  12. 12.
    Burks, T.F. (1973). Mediation by 5-hydroxytryptamine of morphine stimulant actions in dog intestine. J. Pharmacol. Exp. Ther., 185, 539–539Google Scholar
  13. 13.
    Parolaro, D., Sala, M. and Gori, E. (1977). Effect of intracerebroventricular administration of morphine upon intestinal motility in rat and its antagonism with naloxone. Eur. J. Pharmacol., 46, 329–338PubMedCrossRefGoogle Scholar
  14. 14.
    Stewart, J.J., Weisbrodt, N.W. and Burks, T.F. (1978). Central and peripheral actions of morphine on intestinal transit. J. Pharmacol. Exp. Ther., 205, 547–555PubMedGoogle Scholar

Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • T. F. Burks
  • J. J. Galligan
  • L. D. Hirning
  • F. Porreca

There are no affiliations available

Personalised recommendations