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Effect of Peptide YY on Contractile Activity in the Stomach of Heidenhain Pouch Dogs

  • Z. Itoh
  • T. Suzuki
  • M. Nakaya
  • K. Tatemoto
  • V. Mutt

Abstract

A new candidate regulatory peptide, peptide YY (PYY) has been isolated from extracts of the porcine upper small intestine (1), and its chemical structure has been determined (2). PYY has been found to inhibit both secretin- and cholecystokinin-induced pancreatic secretion in anesthetized cats (2). In the present study, the effect of this newly isolated peptide on gastric contractile activity in conscious Heidenhain pouch dogs.

Keywords

Contractile Activity Gastrointestinal Motility Pancreatic Secretion Main Stomach Gastric Body 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Tatemoto, K. and Mutt, V. (1980). Isolation of two novel hormones using a chemical method for finding naturally occurring polypeptide. Nature 285, 417–418.PubMedCrossRefGoogle Scholar
  2. 2.
    Tatemoto, K. (1982). Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic secretion. Proc. Natl. Acad. Sci. USA 79, 2514–2518.PubMedCrossRefGoogle Scholar
  3. 3.
    Itoh, Z., Takeuchi, S., Aizawa, I. and Couch, E.F. (1977). Inhibitory effect of pentagastrin and feeding on natural and motilin-induced interdigestive contractions in the stomach of conscious dogs. Gastroenterol. Jpn. 12, 284–288.PubMedGoogle Scholar
  4. 4.
    Itoh, Z., Takayanagi, R., Takeuchi, S. and Isshiki, S. (1978). Interdigestive motor activity of Heidenhain pouches in relation to main stomach in conscious dogs. Am. J. Physiol. 234, E333–338.PubMedGoogle Scholar

Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • Z. Itoh
  • T. Suzuki
  • M. Nakaya
  • K. Tatemoto
  • V. Mutt

There are no affiliations available

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