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Gastrointestinal Motility Stimulating Properties of Cisapride, a Non-Antidopaminergic Non-Cholinergic Compound

  • J. M. Van Nueten
  • P. G. H. Van Daele
  • A. J. Reyntjens
  • P. A. J. Janssen
  • J. A. J. Schuurkes

Summary

Cisapride, a novel gastrokinetic compound, effectively improves electrically evoked contractions of the guinea pig ileum (ED50 9.2 x 10-9 M) most likely via facilitation of the release of acetylcholine. It also enhances spontaneous contractions of the stomach and induces contractions of colonic strips of the guinea pig. Furthermore, cisapride antagonizes gastric relaxations as induced by adrenergic, dopaminergic and serotonergic agonists or by sympathetic nerve stimulation. The enhanced contractions and reduced relaxations suggest a role for cisapride in gastrointestinal motor disorders.

Keywords

Electrical Stimulation Contractile Response Gastrointestinal Motility Duodenogastric Reflux Sympathetic Nerve Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • J. M. Van Nueten
  • P. G. H. Van Daele
  • A. J. Reyntjens
  • P. A. J. Janssen
  • J. A. J. Schuurkes

There are no affiliations available

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