Advertisement

Interstitial Cells of Cajal: Selective Uptake of Methylene Blue Inhibits Slow Wave Activity

  • L. Thuneberg
  • V. Johansen
  • J. J. Rumessen
  • B. G. Andersen

Abstract

The cellular origin of intestinal slow waves is uncertain. It has been argued (2) that slow waves of small intestine originate in the longitudinal muscle layer, since the recordable activity follows this layer only, upon separation of the muscle layers. Slow-wave amplitudes, measured at various depths within the intact muscularis, reach a maximum at or near the boundary between the longitudinal and circular muscle layers (3, 5).

Keywords

Methylene Blue Muscle Layer Gastrointestinal Motility Slow Wave Activity Circular Muscle Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Barbosa, P. and Peters, T.M. (1971). The effects of vital dyes on living organisms with special reference to methylene blue and neutral red. Histochem. J., 3, 71–93PubMedCrossRefGoogle Scholar
  2. 2.
    Bortoff, A. (1976). Myogenic control of intestinal motility. Physiol. Rev., 56, 418–434PubMedGoogle Scholar
  3. 3.
    Kobayashi, M., Prosser, C. L. and Nagai, T. (1967). Electrical properties of intestinal muscle as measured intracellularly and extracellularly. Am. J. Physiol., 213, 275–286PubMedGoogle Scholar
  4. 4.
    Taylor, A. B., Kreulen, D. and Prosser, C. L. (1977). Electron microscopy of the connective tissues between longitudinal and circular muscle of small intestine of cat. Am. J. Anat., 150, 427–442PubMedCrossRefGoogle Scholar
  5. 5.
    Taylor, G.S., Daniel, E. E. and Tomita, T. (1976). Origin and mechanism of intestinal slow waves. In: Vantrappen, G. (ed). Proc. 5th int. symp. gastrointest. motil. pp. 31–36. ( Herentals: Typoff )Google Scholar
  6. 6.
    Thuneberg, L. (1982). Interstitial cells of Cajal: Intestinal pacemaker cells? Adv. Anat. Embryol. Cell Biol., 71, 1–130PubMedCrossRefGoogle Scholar

Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • L. Thuneberg
  • V. Johansen
  • J. J. Rumessen
  • B. G. Andersen

There are no affiliations available

Personalised recommendations