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D-Pro2, D-Trp7,9 Substance P: an Effective Antagonist of Exogenous and Endogenous Substance P

  • C. Reynolds
  • A. Ouyang
  • S. Cohen

Abstract

Substance P has been identified by immunohistochemical techniques throughout the gastrointestinal tract (1,2). The opposum lower esophageal sphincter contracts in the presence of substance P via direct and indirect mechanisms (3). The role of substance P as a neurotransmitter remains incompletely understood (4,5). The recent development of substance P antagonists (6) may provide a method to define the physiologic effects of substance P. We investigated D-Pro2, D-Trp7,9 substance P on the feline lower esophageal sphincter response to exogenous substance P and to distal esophageal acidification.

Keywords

Lower Esophageal Sphincter Spike Activity Gastrointestinal Motility Lower Esophageal Sphincter Pressure Esophageal Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • C. Reynolds
  • A. Ouyang
  • S. Cohen

There are no affiliations available

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