The Ileal Brake: a Potent Mechanism for Feedback Control of Gastric Emptying and Small Bowel Transit

  • N. W. Read
  • A. McFarlane
  • R. I. Kinsman
  • S. R. Bloom


The absorption of nutrients in the small intestine depends on both the efficiency of the epithelial transport mechanisms and the length of time that nutrients remain in contact with the absorptive epithelium [1, 2]. The existence of neurohumoral mechanisms controlling either of these functions has never been established. The aim of the present study was to investigate the possible existence of a feedback mechanism, whereby the presence of nutrients in the distal small intestine might control small intestinal transit, allowing optimal time for absorption to occur.


Transit Time Gastric Emptying Gastrointestinal Motility Breath Hydrogen Small Intestinal Transit 
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  1. 1.
    Holgate, A.M. and Read, N.W. (1982). Can a rapid small bowel transit limit absorption? Gut, 23, A912.Google Scholar
  2. 2.
    Johansson, C. (1975). Studies of gastrointestinal interactions. V. Characteristics of the absorption pattern of sugar, fat and protein from composite meals in man. A quantitative study. Scand. J. Gastroent., 10, 33–42.PubMedGoogle Scholar
  3. 3.
    Bond, J.H. and Levitt, M.D. (1974). Investigation of small bowel transit time in man utilising pulmonary H2 measurements. J. Lab. Clin. Med., 85, 546–559.Google Scholar
  4. 4.
    Read, N.W., Miles, C.A., Fisher, D., Holgate, A.M., Kime, N.D., Mitchell, M.A., Reeve, A.M., Roche, T.B., and Walker, M. (1980). Transit of a meal through the stomach, small intestine and colon in normal subjects and its role in the pathogenesis of diarrhoea. Gastroenterology, 79, 1276–1282.PubMedGoogle Scholar
  5. 5.
    Corbett, C.L., Thomas, Read, N.W., Hobson, N., Bergman, I. and Holdsworth, C.D. (1981). Electrochemical detector for breath hydrogen determination: measurement of small bowel transit time in normal subjects and patients with the irritable bowel syndrome. Gut, 22, 836–840.PubMedCrossRefGoogle Scholar
  6. 6.
    Spiller, R.G., Bloom, S.R., Silk, D.B.A., Frost, P.G., Brown, B.E., Lee, Y.C. and Ghatei, M.A. (1983). The ileal brake - a compensatory slowing of jejunal transit following ileal fat infusion in man. Clin. Sci. Mol. Med., 63, 53P.Google Scholar
  7. 7.
    Holst, J.J. (1978). Extrapancreatic glucagons. Digestion, 17, 168–190.PubMedCrossRefGoogle Scholar
  8. 8.
    Rosell, S. and Rokaeus, A. (1979). The effect of ingestion of amino acids, glucose and fat on circulating neurotensin-like immunoreactivity (NTLI) in man. Acta. Physiol. Scand., 107, 263–267.PubMedCrossRefGoogle Scholar
  9. 9.
    Besterman, S., Sarson, D.L., Blackburn, A.M., Cleary, J., Pilkington, T.R.E. and Bloom, S.R. (1978). The gut hormone profile in morbid obesity and following jejuno-ileal by pass. Scand. J. Gastroenterol., Suppl. 49, 15.Google Scholar
  10. 10.
    Holst, J.J., Sorensen, T.I.A., Andersen, A.N., Stadil, F., Andersen, B., Lauritsen, K.B. and Klein, H.C. (1979). Plasma enteroglucagon after jejuno-ileal by-pass with a 3:1 or 1:3 jejuno-ileal ratio. Scand. J. Gastroenterol., 14, 205–207.PubMedCrossRefGoogle Scholar
  11. 11.
    Go, V.L.W. and Demol, P. (1981). Role of nutrients in gastrointestinal release of immunoreactive neurotensin. Peptides, 2 (Suppl. 2), 267–269.PubMedCrossRefGoogle Scholar
  12. 12.
    Ferris, C.F., Hammer, R.A. and Leeman, S.E. (1981). Elevation of plasma neurotensin during lipid perfusion of rat small intestine. Peptides, 2 (Suppl. 2), 263–266.PubMedCrossRefGoogle Scholar

Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • N. W. Read
  • A. McFarlane
  • R. I. Kinsman
  • S. R. Bloom

There are no affiliations available

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