Stimulation of Action Potential Complexes by Fluid Distension of Rabbit Small Intestine — Evidence that Migrating Action Potential Complexes are a Non-specific Myoelectric Response
Migrating action potential complexes (MAPC’s) are an abnormal motility pattern that have primarily been associated with certain bacterial enterotoxins.1–5 It has been reported that sudden, luminal distension in vivo does not result in MAPC’s.l However, the peristaltic reflex due to sudden in vitro luminal distension has been reported to result in aborally propagating action potentials and contraction rings.6–8 Neither approach has studied the effects of gradual luminal distension which would be more likely to occur in clinical diarrheal illness. An association of action potential bursts with fluid production has been reported in rabbits infected with Salmonella in vivo, but the contribution of luminal distension per se was not assessed.9 The purpose of this study was to describe the effect of gradual in vivo luminal distension on myoelectric activity.
KeywordsGastrointestinal Motility Myoelectric Activity ILEAL Loop Spike Burst Fluid Output
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