Peptides: The Wave of the Future pp 1031-1032 | Cite as
B-Cell Linear Epitopes in the Conservative Regions of Hepatitis C Virus Envelope Glycoproteins
Chapter
Abstract
Hepatitis C virus (HCV) infection in 80% cases causes chronic hepatitis C development, often resulting in cirrhosis and hepatocarcinonaa. High variability of HCV El and E2 envelope protein fragments, to which virus-neutralizing antibodies are formed in the natural course of infection, enables the virus to escape from the host immune response. Nevertheless, El and E2 sequences contain highly conservative sites that may be responsible for all attachment and entry and may elicit protective antibodies [1–3]. However, these sites have not been defined and their immunogenicity has not been subjected to regular studies.
Keywords
Biomedical Chemistry Conservative Region Conservative Site Virus Envelope Glycoprotein Convalescent Seron
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Copyright information
© Springer Science+Business Media Dordrecht 2001