Peptides: The Wave of the Future pp 52-53 | Cite as
New Approach for Preparation of C-Glycoamino Acid Building Blocks
Chapter
Abstract
Oxygen-linked glycopeptides are vital constituents of biological membranes and their carbohydrate moieties play key role in molecular recognition processes [1]. However, O-glycosidic bonds in these molecules are sensitive to both chemical and enzymatic deglycosylation. Preparation of the hydrolytically more stable C-glycosylated analogs has attracted much attention recently. The objectives of this study were to prepare β-and β-amino acids ß-linked to the carbohydrate moiety as building blocks in combinatorial approaches to generate glycopeptide mimetics by solid phase peptide synthesis methods.
Keywords
Boron Trifluoride Carbohydrate Moiety Sodium Cyanide Racemic Amino Acid Enzymatic Deglycosylation
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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