Composition and Structural Dynamics of Vertebrate Striated Muscle Thick Filaments

Role of Myosin-associated Proteins
  • Zoya A. Podlubnaya
Conference paper
Part of the NATO Science Series book series (ASHT, volume 87)

Abstract

We discuss recent data on integral and dynamic (muscle state-dependent) protein components of vertebrate striated muscles thick filaments. Their contribution to the structural dynamics of the filaments and in particular, to Ca2+-dependent reversible structural transitions involving the domains of myosin molecules arranged on the filament surface, is analyzed. The functional importance of these transitions is considered in the context of the mechanisms regulating the contractile process and its coupling with energy metabolism.

Keywords

Skeletal and cardiac muscle force generation regulation structural transitions myosin filaments enzymes of energy metabolism titin and titin-like proteins 
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Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • Zoya A. Podlubnaya
    • 1
  1. 1.Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences, PushchinoMoscow RegionRussia

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