Modified Porous Silicon Surfaces as DIOS-MS Sample Plates

  • Santeri Tuomikoski
  • Katri Huikko
  • Pekka Östman
  • Kestas Grigoras
  • Marc Baumann
  • Risto Kostiainen
  • Sami Franssila
  • Tapio Kotiaho
Conference paper

Abstract

This study presents a novel porous silicon (pSi) fabrication method for the matrix-free desorption/ionization on silicon mass spectrometry (DIOS-MS). The fabrication conditions and surface treatments of pSi on DIOS-MS performance are explored. Utilization of pSi sample plates in the analysis of low molecular weight pharmaceutical compounds is shown.

Keywords

desorption/ionization mass spectrometry porous silicon pharmaceuticals 
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References

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    S. Tuomikoski, K. Huikko, K. Grigoras, A.J. Niskanen, T. Kotiaho, R. Kostiainen, S. Franssila, M. Baumann, Preparation of Porous n-type Silicon Sample Plates for Desorption/Ionization Mass Spectrometry (DIOS MS), NanoTech 2001 Conference, Montreux, Switzerland, 27. — 29. November, 2001.Google Scholar
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Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • Santeri Tuomikoski
    • 1
  • Katri Huikko
    • 2
  • Pekka Östman
    • 2
  • Kestas Grigoras
    • 1
  • Marc Baumann
    • 3
  • Risto Kostiainen
    • 2
  • Sami Franssila
    • 1
  • Tapio Kotiaho
    • 2
  1. 1.Microelectronics CentreHelsinki University of TechnologyFinland
  2. 2.DDTC, Department of PharmacyUniversity of HelsinkiFinland
  3. 3.Protein Chemistry Unit, Biomedicum HelsinkiUniversity of HelsinkiFinland

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