Advertisement

Functionalized Parylene Coatings for Microfluidic Applications

  • Jörg Lahann
  • Mercedes Balcells
  • Hang Lu
  • Teresa Rodon
  • Klavs F. Jensen
  • Robert Langer
Conference paper

Abstract

The need to increase the throughput of drug-discovery processes while reducing costs continues to drive the development of microfluidic assays. The deposition of thin polymer films that establish chemically defined interfaces offers a unique way to overcome these limitations. We report a stable and functionalized modification of PDMS microfluidic devices by chemical vapor deposition (CVD) polymerization with poly[para-xylylene] coatings. These coating further has the advantages of allowing deposition over complex three dimensional geometries and into cavities — as long as the latter allow sufficient diffusion.

Keywords

CVD reactive coating surface modification cell assay 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    McConnell, H.M. et al. Science 1992, 257, 1906.CrossRefGoogle Scholar
  2. 2.
    Duffy, D.C.; MacDonald J.C.; Schueller O.J.A.; Whitesides G.A. Anal. Chem. 1998, 70, 4974.CrossRefGoogle Scholar
  3. 3.
    Lahann, J.; Balcells, M.; Rodon, T., Lee, J.; Choi, I.S.; Jensen, K.F.; Langer R. Langmuir 2002, 18, 3632.CrossRefGoogle Scholar
  4. 4.
    Dennis, M.S.; Henzel, W.J.; Pitti, R.M.; Lipari, M.T.; Napier, M.A.; Deisher, T.A.; Bunting, S.; Lazarus, R.A. Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 2471.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • Jörg Lahann
    • 1
  • Mercedes Balcells
    • 1
    • 2
  • Hang Lu
    • 1
  • Teresa Rodon
    • 1
  • Klavs F. Jensen
    • 1
  • Robert Langer
    • 1
  1. 1.Massachusetts Institute of TechnologyCambridgeUSA
  2. 2.Institut Químic de SarriàBarcelonaSpain

Personalised recommendations