Experimental Brain Metastasis

  • Kenneth W. Brunson
  • Garth L. Nicolson
Chapter
Part of the Metastasis: A Monograph Series book series (METS, volume 2)

Abstract

Tumor metastasis is a complex, multistep process that appears to be dependent upon a number of host and tumor properties (Fidler 1975a; Weiss 1977a; Fidler and Nicolson 1979; Nicolson 1978a). First, emergent malignant tumor cells must be able to survive and grow in a potentially hostile environment and proliferate to form a primary tumor. Once a primary tumor is established, invasion of surrounding normal tissues may take place by mechanical infiltration (Eaves 1973), enzymatic digestion (Dresden et al. 1972), or both. If a primary tumor is able to penetrate blood vessels, malignant cells can be transported to distant sites. Several factors probably influence tumor-cell detachment (Weiss 1977b) and survival in the circulation. While in the blood, tumor cells (or cell emboli) can interact with a variety of humoral or cellular components (such as lymphocytes, platelets, endothelial cells). The hostile environment of the circulatory system probably causes the death of most blood-borne malignant cells originating from solid tumors; only a small percentage of tumor cells actually survive to form secondary tumors (Fidler 1970, 1976). Survival at a distant site appears to involve successful implantation in the microcirculation, extravasation and establishment of a proper environment for subsequent vascularization and growth.

Keywords

Melanoma Cell Retinoic Acid Brain Metastasis Melanoma Line Variant Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© G.K. Hall & Co. 1980

Authors and Affiliations

  • Kenneth W. Brunson
  • Garth L. Nicolson

There are no affiliations available

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