Orotic Acid pp 26-30 | Cite as

Inhibitors of the Orotate Pathway

  • Alois Čihák
  • Werner Reutter
Chapter

Abstract

The first known drug affecting the orotate pathway was 6-azauridine [245,246]. This analogue is phosphorylated to 6-azauridine 5′-monophosphate which acts as a competitive inhibitor of orotidylic acid decarboxylase [247]. Therapeutic use of 6-azauridine [248,249] is occasionally complicated by a pronounced crystalluria. Owing to the block of orotidylic acid decarboxylase, large amounts of orotidine and orotic acid are excreted in urine. After the infusion of 6-azauridine the excretion of orotic acid precedes orotidine and the former disappears more rapidly from the urine. Psoriatic patients on azaribine (triacetylated form of 6-azauridine given orally) excreted 0.2–1.3 g of orotic acid and orotidine per day [250].

Keywords

Barbituric Acid Psoriatic Patient Orotic Acid Phenethyl Alcohol Pyrimidine Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© A. Čihák and W. Reutter 1980

Authors and Affiliations

  • Alois Čihák
    • 1
  • Werner Reutter
    • 2
  1. 1.Institute of Organic Chemistry and BiochemistryCzechoslovakia Academy of Sciences PragueCzechoslovakia
  2. 2.Institut für Molekularbiologie und Biochemie der Freien UniversitätBerlinGermany

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