γ-Glutamyl transpeptidase: catalytic, structural and functional aspects

  • Suresh S. Tate
  • Alton Meister
Chapter
Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 1)

Summary

γ -Glutamyl transpeptidase catalyzes transfer of the γ -glutamyl moiety of glutathione to amino acids, dipeptides, and to glutathione itself; the enzyme also catalyzes the hydrolysis of glutathione to glutamate and cysteinyl-glycine. This review deals with the tissue distribution and localization of the enzyme in mammals, the catalytic properties of the enzyme (including its inhibition by reversible and irreversible inhibitors), structural studies on the enzyme, and new findings about its physiological function.

Keywords

Glutathione Disulfide Microvillus Membrane Heavy Subunit Amino Acid Acceptor Light Subunit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Meister, A. & Tate, S. S., 1976. Ann. Rev. Biochem. 45: 559–604.PubMedCrossRefGoogle Scholar
  2. 2.
    Meister, A., 1981. In Current Topics of Cellular Regulation (Horecker, B. & Stadtman, E.,eds.), vol. 18,18:21–57.Google Scholar
  3. 3.
    Meister, A., 1975. In Metabolism of Sulfur Compounds, Metabolic Pathways, 3rd edition (Greenberg, D. M., ed.), 7: 101–188, Academic Press.Google Scholar
  4. 4.
    Dakin, H. D. & Dudley, H. W., 1913. J. Biol. Chem. 15: 463–474Google Scholar
  5. 5.
    Meister, A., Tate, S. S. & Ross, L. L., 1976. In The Enzymes of Biological Membranes (Martinosi, A., ed.), vol. 3, Plenum Press, New York, pp. 315–347.Google Scholar
  6. 6.
    Tate, S. S., 1980. In Enzymatic Basis of Detoxication (Jakoby, W. B., ed.), vol. 2, Academic Press, pp. 95–120.Google Scholar
  7. 7.
    Meister, A., Griffith, O. W., Novogrodsky, A. & Tate, S. S., 1980. Ciba Fdn. Symp. 72: 135–161.Google Scholar
  8. 8.
    Goldberg, D. M., 1980. Critical Reviews in Clinical Laboratory Sciences 12: 1–58.PubMedCrossRefGoogle Scholar
  9. 9.
    Rosalki, S. B., 1975. Adv. Clin. Chem. 17: 53–107.PubMedCrossRefGoogle Scholar
  10. 10.
    Cornell, J. S. & Meister, A., 1976. Proc. Natl. Acad. Sci. U.S.A. 73: 420–422.Google Scholar
  11. 11.
    Heinle, H., Wendel, A. & Schmidt, U., 1977. FEBS Lett. 73: 220–224.PubMedCrossRefGoogle Scholar
  12. 12.
    Novogrodsky, A., Tate, S. S. & Meister, A., 1976. Proc. Natl. Acad. Sci. U.S.A. 73: 2414–2418.Google Scholar
  13. 13.
    Albert, Z., Orlowski, M. & Szewczuk, A., 1961. Nature (London) 191: 767–768.CrossRefGoogle Scholar
  14. 14.
    Glenner, G. G., Folk, J. E. & McMillan, P. J., 1962. J. Histochem. Cytochem. 10: 481–489.Google Scholar
  15. 15.
    Marathe, G. V., Nash, B., Haschemeyer, R. H. & Tate, S. S., 1979. FEBS Lett. 107: 436 - 440.PubMedCrossRefGoogle Scholar
  16. 16.
    Marathe, G. V., Damle, N. S., Haschemeyer, R H. & Tate, S. S., 1980. FEBS Lett. 115: 273–277.PubMedCrossRefGoogle Scholar
  17. 17.
    Horiuchi, S., Inoue, M. & Morino, Y., 1978. Eur. J. Biochem. 87: 429–437.PubMedCrossRefGoogle Scholar
  18. 18.
    Tsao, B. & Curthoys, N. P., 1980. J. Biol. Chem. 255: 7708–7711.PubMedGoogle Scholar
  19. 19.
    Orlowski, M. & Meister, A., 1963. Biochim. Biophys. Acta 73: 679–681.Google Scholar
  20. 20.
    Tate, S. S. & Meister, A., 1974. J. Biol. Chem. 249: 7593–7602.PubMedGoogle Scholar
  21. 21.
    Tate, S. S., 1975. FEBS Lett. 54: 319–322.PubMedCrossRefGoogle Scholar
  22. 22.
    Smith, G. D., Ding, J. L. & Peters, T. J., 1979. Anal. Biochem. 100: 136–139.PubMedCrossRefGoogle Scholar
  23. 23.
    Griffith, O. W. & Meister, A., 1977. Proc. Natl. Acad. Sci. U.S.A. 74: 3330–3334.Google Scholar
  24. 24.
    Thompson, G. A. & Meister, A., 1977. J. Biol. Chem. 252: 6792–6798.PubMedGoogle Scholar
  25. 25.
    Thompson, G. A. & Meister, A., 1976. Biochem. Biophys. Res. Commun. 71: 32–36.PubMedCrossRefGoogle Scholar
  26. 26.
    Ball, E. G., Revel, J. P. & Cooper, O., 1956. J. Biol. Chem. 221: 895–908.Google Scholar
  27. 27.
    Tate, S. S. & Meister, A., 1974. Proc. Natl. Acad. Sci. U.S.A. 71: 3329–3333.PubMedCrossRefGoogle Scholar
  28. 28.
    Mclntyre, T. M. & Curthoys, N. P., 1979. J. Biol. Chem. 254: 6499–6504.Google Scholar
  29. 29.
    Allison, D. & Meister, A., 1981. J. Biol. Chem. 266: 2988–2992.Google Scholar
  30. 30.
    Orlowski, M. & Meister, A., 1965. J. Biol. Chem. 240: 338–347.PubMedGoogle Scholar
  31. 31.
    Tate, S. S. & Meister, A., 1977. Proc. Natl. Acad. Sci. U.S.A. 74: 931–935.Google Scholar
  32. 32.
    Inoue, M., Horiuchi, S. & Morino, Y., 1977. Eur. J. Biochem. 73: 335–342.PubMedCrossRefGoogle Scholar
  33. 33.
    Tate, S. S. & Meister, A., 1978. Proc. Natl. Acad. Sci. U.S.A. 5: 4806–4809.CrossRefGoogle Scholar
  34. 34.
    Gardell, S. J. & Tate, S. S., 1979, J. Biol. Chem. 254: 4942–4945.Google Scholar
  35. 35.
    Holzer, H. & Heinrich, P. C., 1980. Annu. Rev. Biochem. 49: 63–91.PubMedCrossRefGoogle Scholar
  36. 36.
    Tate, S. S., Grau, E. M. & Meister, A., 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 2715–2719.Google Scholar
  37. 37.
    Tate, S. S. & Orlando, J., 1979. J. Biol. Chem. 254: 5573–5575.PubMedGoogle Scholar
  38. 38.
    Griffith, O. W. & Tate, S. S., 1980. J. Biol. Chem. 255: 5011–5014.Google Scholar
  39. 39.
    Jones, D. P., Moldeus, P. & Orrenius, S., 1979. J. Biol. Chem. 254: 2787–2792.Google Scholar
  40. 40.
    Anderson, M. E., Bridges, R. J. & Meister, A., 1980. Biochim. Biophys. Res. Commun. 96: 848–853.CrossRefGoogle Scholar
  41. 41.
    Janolino, V. G. & Swaisgood, H. E., 1975. J. Biol. Chem. 250: 2532–2538.PubMedGoogle Scholar
  42. 42.
    Ostrowski, M. C. & Kistler, W. S., 1980. Biochemistry 19: 2639–2645.PubMedCrossRefGoogle Scholar
  43. 43.
    Flohé, L., Günzler, W. A. & Ladenstein, R., 1976. In Glutathione: Metabolism and Function (Arias, I. M. & Jakoby, W. B., editors), pp. 115–138, Raven Press, New York.Google Scholar
  44. 44.
    Revel, J. P. & Ball, E. G., 1959. J. Biol. Chem. 234: 577–582.Google Scholar
  45. 45.
    Kinoshita, T. & Minato, S., 1978. Bull. Chem. Soc. of Japan 51: 3282–3285.CrossRefGoogle Scholar
  46. 46.
    Minato, S., 1979. Arch. Biochem. Biophys. 192: 235–240.Google Scholar
  47. 47.
    Griffith, O. W. & Meister, A., 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 268–272.PubMedCrossRefGoogle Scholar
  48. 48.
    Binkley, F., 1961. J. Biol. Chem. 236: 1075–1082.Google Scholar
  49. 49.
    Tate, S. S. & Meister, A., 1975. J. Biol. Chem. 250: 4619–4627.PubMedGoogle Scholar
  50. 50.
    Curthoys, N. P. & Kuhlenschmidt 1975. J. Biol. Chem. 250: 2099–2105.Google Scholar
  51. 51.
    Thompson, G. A. & Meister, A., 1979. J. Biol. Chem. 254: 2956–2960.Google Scholar
  52. 52.
    Thompson, G. A. & Meister, A., 1980. J. Biol. Chem. 255: 2109–2113.PubMedGoogle Scholar
  53. 53.
    Allen, L., Meek, R. & Yunis, A., 1980. Res. Commun. Chem. Pathol. Pharmacol. 27: 175–182.Google Scholar
  54. 54.
    Griffith, O. W. & Meister, A., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 3384–3387.PubMedCrossRefGoogle Scholar
  55. 55.
    Gardell, S. J. & Tate, S. S., 1980. FEBS Lett. 122: 171–174.PubMedCrossRefGoogle Scholar
  56. 56.
    Kozak, E. M. &Tate, S. S., 1980. FEBS Lett. 122: 175–178.PubMedCrossRefGoogle Scholar
  57. 57.
    Inoue, M., Horiuchi, S. & Morino, Y., 1978, Biochem. Biophys. Res. Comm. 82: 1183–1188.Google Scholar
  58. 58.
    Tate, S. S. & Meister, A., 1976. Proc. Natl. Acad. Sci. U.S.A. 73: 2599–2603.PubMedCrossRefGoogle Scholar
  59. 59.
    Tate, S. S. & Ross, M. E., 1977. J. Biol. Chem. 252: 6042–6045.Google Scholar
  60. 60.
    Zelazo, P. & Orlowski, M., 1976. Eur. J. Biochem. 61: 147–155.PubMedCrossRefGoogle Scholar
  61. 61.
    Hughey, R. P. & Curthoys, N. P., 1976. J. Biol. Chem. 251: 7813–7870.Google Scholar
  62. 62.
    Kottgen, E., Reuter, W. & Gerok, W., 1978. Eur. J. Biochem. 82: 279–284.PubMedCrossRefGoogle Scholar
  63. 63.
    Jaken, S. & Mason, M., 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 1750–1753.Google Scholar
  64. 64.
    DeLap, L. W., Tate, S. S. & Meister, A., 1977. Life Sci. 20: 673–680.PubMedCrossRefGoogle Scholar
  65. 65.
    Gardell, S. J. & Tate, S. S., 1981. J. Biol. Chem. 256: 4799–4804.PubMedGoogle Scholar
  66. 66.
    Hughey, R. P., Coyle, P. J. & Curthoys, N. P., 1979. J. Biol. Chem. 254: 1124–1128.PubMedGoogle Scholar
  67. 67.
    Tsuji, A., Matsuda, Y. & Katunuma, N., 1980. J. Biochem. ( Tokyo ) 87: 1567–1571.Google Scholar
  68. 68.
    Nash, B., 1980. Fed. Proc. 39: 1866.Google Scholar
  69. 69.
    Taniguchi, N., 1974. J. Biochem. ( Tokyo ) 75: 473–480.Google Scholar
  70. 70.
    Shaw, L. M., London, J. W. & Petersen, L. E., 1978, Clin. Chem. 24: 905–916.PubMedGoogle Scholar
  71. 71.
    Hanes, C. S., Hird, F. J. R. & Isherwood, F. A., 1950. Nature (Lond.) 166: 288–292.CrossRefGoogle Scholar
  72. 72.
    Hanes, C. S., Hird, F. J. R. & Isherwood, F. A., 1952. Biochem. J. 51: 25–35.PubMedGoogle Scholar
  73. 73.
    Griffith, O. W., Bridges, R. J. & Meister, A., 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 6319–6322.Google Scholar
  74. 74.
    Buchanan, D. L., Haley, E. E. & Markiw, R. T., 1962. Biochem. 1: 612–620.CrossRefGoogle Scholar
  75. 75.
    Peck, H. & Pollitt, R. J., 1979. Clin. Chem. Acta 94: 237–240.Google Scholar
  76. 76.
    Kakimoto, Y., Nakajima, T., Kanazawa, A. Takesada, M. & Sano, I., 1964. Biochim. Biophys. Acta 93: 333–338.Google Scholar
  77. 77.
    Reichelt, K. L., 1970. J. Neurochem. 17: 19–25.PubMedCrossRefGoogle Scholar
  78. 78.
    Versteeg, D. H. G. & Witter, A., 1970. J. Neurochem. 17: 41–52.CrossRefGoogle Scholar
  79. 79.
    Kanazawa, A., Kakimoto, Y. Nakajima, T. & Sano, I., 1965. Biocheim. Biophys. Acta 111: 90–95.Google Scholar
  80. 80.
    Sano, I., 1970. Int. Rev. Neurobiol. 12: 235–263.PubMedCrossRefGoogle Scholar
  81. 81.
    Wendel, A., Hahn, R. & Guder, W. G., 1976. Curr. Probl. Clin. Biochem. 6: 426–436.Google Scholar
  82. 82.
    Palekar, A. G., Tate, S. S. & Meister, A., 1975. Biochem. Biophys. Res. Commun. 62: 651–657.PubMedCrossRefGoogle Scholar
  83. 83.
    Griffith, O. W., Bridges, R. J. & Meister, A., 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 5405–5408.Google Scholar
  84. 84.
    Ormstad, K., Jones, D. P. & Orrenius, S., 1980. J. Biol. Chem. 255: 175–181.Google Scholar
  85. 85.
    Ormstad, K., Lastbom, T. & Orrenius, S., 1980. FEBS Lett. 112: 55–59.PubMedCrossRefGoogle Scholar
  86. 86.
    Elce, J. S. & Broxmeyer, B., 1976. Biochem. j. 153: 223–232.PubMedGoogle Scholar
  87. 87.
    Fersht, A., 1977. Enzyme Structure and Mechanism, pp. 253–259, W. H. Freeman, San Francisco.Google Scholar
  88. 88.
    Srere, P. A., 1967. Science 158: 936–937.PubMedCrossRefGoogle Scholar
  89. 89.
    Cagen, L. M., Fales, H. M. & Pisano, J. J., 1976. J. Biol. Chem. 251: 6500–6554.Google Scholar
  90. 90.
    Cagen, L. M. & Pisano, J. J., 1979. Biochim. Biophys. Acta 573: 547–551.PubMedGoogle Scholar
  91. 91.
    Örning, L., Hammarström, S. & Samuelsson, B., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 2014–2017.PubMedCrossRefGoogle Scholar
  92. 92.
    Hammerstrom, S., Samuelsson, B., Clark, D. A., Groto, G., Marfat, A., Miowskowski, C. & Corey, E. J., 1980. Biochem. Biophys. Res. Commun. 92: 946–953.Google Scholar
  93. 93.
    Kuss, E., 1967. Hoppe-Seylers Z. Physiol. Chem. 348: 1707–1708.PubMedGoogle Scholar
  94. 94.
    Kuss, E., 1968. Hoppe-Seyler’s Z. Physiol. Chem. 349: 1234–1236.Google Scholar
  95. 95.
    Kuss, E., 1969. Hoppe-Seyler’s Z. Physiol. Chem. 350: 95–97.PubMedGoogle Scholar
  96. 96.
    Elce, J. S., 1970. Biochem. J. 116: 913–917.PubMedGoogle Scholar
  97. 97.
    Jellinck, P. H., Lewis, J. & Boston, F., 1967. Steroids 10: 329–346.PubMedCrossRefGoogle Scholar
  98. 98.
    Perantoni, A., Berman, J. J. & Rice, J. M., 1979. Exp. Cell. Res. 122: 55–61.Google Scholar
  99. 99.
    Pine, E. K., 1958. J. Nat. Cancer Inst. 21: 973–984.PubMedGoogle Scholar
  100. 100.
    Schulman, J. D., Goodman, S. I., Mace, J. W., Patrick, A. D., Tietze, F. & Butler, E. J., 1975. Biochem. Biophys. Res. Commun. 65: 68–74.Google Scholar
  101. 101.
    Wright, E. C., Stern, J., Ersser, R. & Patrick, A. D., 1979. Journal of Inherited Metabolic Disease 2: 3–7.CrossRefGoogle Scholar
  102. 102.
    Meister, A., 1977. In The Metabolic Basis of Inherited Disease (4th ed.), (Stanbury, J. B., Wyngaarden, J. B. & Frederickson, D. S., editors), pp. 328–336, McGraw-Hill.Google Scholar
  103. 103.
    Thompson, G. A. & Meister, A., 1976. Biochem. Biophys. Res. Commun. 71: 32–36.PubMedCrossRefGoogle Scholar
  104. 104.
    Griffith, O. W., Bridges, R. J. & Meister, A., 1981. Proc. Natl. Acad. Sci. 78: 2777–2781.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff/Dr W. Junk Publishers, The Hague 1981

Authors and Affiliations

  • Suresh S. Tate
    • 1
  • Alton Meister
    • 1
  1. 1.Dept. of BiochemistryCornell University Medical CollegeNew YorkUSA

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